Last update 15 Nov 2025

SB-4826

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms-
Target
SAE1
Action
inhibitors
Mechanism
SAE1 inhibitors(SUMO1 activating enzyme subunit 1 inhibitors)
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases
Active Indication
Indolent Non-Hodgkin LymphomaLocally Advanced Malignant Solid NeoplasmNeoplasms
Inactive Indication-
Originator Organization
Oncovalent Therapeutics, Inc.Oncovalent Therapeutics, Inc.
Active Organization
University of California San DiegoUniversity of California San DiegoOncovalent Therapeutics, Inc.Oncovalent Therapeutics, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with SB-4826
NCT07222631
/ Not yet recruitingPhase 1/2IIT
An Open-Label, First-in-Human Phase 1/2, Dose-Escalation and Dose-Expansion/ Combination Therapy Study to Investigate Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Efficacy of SB-4826 as a Single Agent in Adult Participants With Locally Advanced or Metastatic Solid Tumors or Non-Hodgkin Lymphomas and in Combination With Rituximab in Adult Participants With Non-Hodgkin Lymphomas.
100 Clinical Results associated with SB-4826
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100 Translational Medicine associated with SB-4826
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100 Patents (Medical) associated with SB-4826
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100 Deals associated with SB-4826
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Indolent Non-Hodgkin LymphomaPhase 2
United States
University of California San DiegoUniversity of California San Diego
01 Feb 2026
Locally Advanced Malignant Solid NeoplasmPhase 2
United States
University of California San DiegoUniversity of California San Diego
01 Feb 2026
NeoplasmsPreclinical
United States
Oncovalent Therapeutics, Inc.Oncovalent Therapeutics, Inc.
14 Apr 2023
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Core Patent

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Clinical Trial

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Approval

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Regulation

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