Request Demo

Last update 20 Mar 2025

Dibazol

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Bendazolum

Target-

Action-

Mechanism-

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC14H12N2

InChIKeyYTLQFZVCLXFFRK-UHFFFAOYSA-N

CAS Registry621-72-7

100 Clinical Results associated with Dibazol

100 Translational Medicine associated with Dibazol

100 Patents (Medical) associated with Dibazol

975

Literatures (Medical) associated with Dibazol

25 Feb 2025·Chemistry – A European Journal

Intermolecular 1,2‐Difunctionalization of Nitriles via Redox Gold Catalysis: Synthesis of Benzoxazoles and Benzimidazoles

Article

Author: Chen, Ming ; Liu, Yuanhong ; Xu, Zhenyan ; Chen, Yifeng ; Xu, Chengzhi

AbstractThe unprecedent gold‐catalyzed intermolecular 1,2‐difunctionalization of nitriles with o‐iodophenols or o‐iodoanilines via Au(I)/Au(III) redox catalysis has been developed, providing an expedient route to the synthesis of benzoxazoles or benzimidazoles with broad substrate scope and high functional compatibility. Mechanistic investigation reveals that the Au(III)‐Ar species generated via oxidative addition of o‐iodophenol to MeDalphosAu+, serves as a key intermediate. Particularly, this annulation is initiated by oxidative addition, rather than the nucleophilic attack of the phenol moiety in o‐iodophenol towards the nitrile. The method was also applied to the synthesis of poly aza‐heterocycles via a cascade Au(I)/Au(III) and Au(I) catalysis relay.

01 Jan 2025·Progress in Organic Coatings

Novel fluorobenzimidazole-assisted heat resistant anticorrosion copper surface for high-density interconnected printed circuit boards

Author: Weng, Xingshang ; Zhuang, Xuewen ; Chen, Weijian ; Yang, Zongmei ; Zhang, Xiaochun ; Chen, Zhongming

Self-assembled organic films of imidazole derivatives are vital for metal surface modification, but their effectiveness in the commercialization of high-d. copper interconnects remains limited.To enhance thermal and chem. stability, we synthesized five fluorobenzimidazole monomers by integrating fluorine into the imidazole structure using a solvent-free method.Notably, the 5-chloro-2-(2-chloro-4-fluorobenzyl)-1H-benzo[d]imidazole (5224FIM) demonstrated an impressive inhibition efficiency of 95.00%, forming a robust barrier approx. 4450 Å thick, which effectively withstands damage under high temperature and humidity.XPS anal. revealed that the oxygen content in sample 5442FIM was 9.02%, the lowest among the samples, while the nitrogen content was 8.19%, indicating a substantial presence of imidazole mols.In comparison to non-substituted benzimidazole films, these fluorine-enhanced self-assembled films on copper exhibited superior heat and moisture resistance.Notably, printed circuit boards coated with 5224FIM demonstrated excellent performance in 72-h salt spray and 245°C tin immersion solderability tests, highlighting their enhanced surface protection capabilities.

16 Dec 2024·Chemistry – An Asian Journal

Copper‐Catalyzed Trifunctionalization of Heteroaryl‐Substituted 1‐Hexenes via Remote Heteroaryl Migration

Article

Author: Shang, Jiayi ; Sun, Yanwen ; Guo, Kang ; Wu, Qiong ; Lu, Yongchao ; Sun, Yining

AbstractA copper‐catalyzed trifunctionalization (trifluoromethylation, heteroarylation, and cyanation) of heteroaryl‐substituted 1‐hexenes via remote heteroaryl migration is reported. A variety of CF3 and heteroaryl‐containing nitriles were readily constructed under mild conditions. The reaction features high chemo‐ and regioselectivities and represents a convenient method for the synthesis of multifunctionalized molecules in organic synthesis.

100 Deals associated with Dibazol

R&D Status

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

Dibazol

Overview

Basic Info

Structure/Sequence

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation