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Clinical Trials associated with GPC3/CD146 CAR-T cells(Essen Biotech)Phase 1/2 Study of Sequential CD146 and GPC3 CAR-T Cell Therapy in Advanced Ovarian Cancer
This is a multicenter, open-label Phase 1/2 clinical trial evaluating the safety and preliminary efficacy of sequentially administered CD146-targeted and GPC3-targeted CAR-T cell therapy in patients with advanced relapsed or refractory ovarian cancer. Eligible patients will undergo lymphodepleting chemotherapy with cyclophosphamide and fludarabine, followed by an infusion of autologous CD146-directed CAR-T cells (Arm A) and a subsequent infusion of autologous GPC3-directed CAR-T cells (Arm B). The Phase 1 portion will assess safety, tolerability, and dose-limiting toxicities (DLTs) to determine a recommended Phase 2 dose, while the Phase 2 portion will evaluate efficacy endpoints including objective response rate (ORR), progression-free survival (PFS), and overall survival (OS). Patients will be followed for up to 36 months after CAR-T infusion to monitor long-term outcomes and adverse events.
100 Clinical Results associated with GPC3/CD146 CAR-T cells(Essen Biotech)
100 Translational Medicine associated with GPC3/CD146 CAR-T cells(Essen Biotech)
100 Patents (Medical) associated with GPC3/CD146 CAR-T cells(Essen Biotech)
100 Deals associated with GPC3/CD146 CAR-T cells(Essen Biotech)