Epilepsy is a chronic disorder characterized by disturbed tissue related molecular activity within the brain irrespective of age. The cause is very difficult to understand towards a suitable treatment. However, its symptoms like seizures are treated and suppressed by known medications. Moreover, the condition is linked with neuro-transmitters such as GABA (gamma amino butyric acid) and acetylcholine. Therefore, it is of interest to design and develop inhibitors for these targets. Hence, we describe the molecular binding features of timepidium with acetylcholine and lumacaftor with GABA(A) activator using molecular docking based geometric optimization and screening analysis for further consideration.

01 Dec 2018·Chemistry Central Journal

Therapeutic importance of synthetic thiophene

Review

Author: Verma, Prabhakar Kumar ; Shah, Rashmi

Thiophene and its substituted derivatives are very important class of heterocyclic compounds which shows interesting applications in the field of medicinal chemistry. It has made an indispensable anchor for medicinal chemists to produce combinatorial library and carry out exhaustive efforts in the search of lead molecules. It has been reported to possess a wide range of therapeutic properties with diverse applications in medicinal chemistry and material science, attracting great interest in industry as well as academia. It has been proven to be effectual drugs in present respective disease scenario. They are remarkably effective compounds both with respect to their biological and physiological functions such as anti-inflammatory, anti-psychotic, anti-arrhythmic, anti-anxiety, anti-fungal, antioxidant, estrogen receptor modulating, anti-mitotic, anti-microbial, kinases inhibiting and anti-cancer. Thus the synthesis and characterization of novel thiophene moieties with wider therapeutic activity is a topic of interest for the medicinal chemist to synthesize and investigate new structural prototypes with more effective pharmacological activity. However, several commercially available drugs such as Tipepidine, Tiquizium Bromides, Timepidium Bromide, Dorzolamide, Tioconazole, Citizolam, Sertaconazole Nitrate and Benocyclidine also contain thiophene nucleus. Therefore, it seems to be a requirement to collect recent information in order to understand the current status of the thiophene nucleus in medicinal chemistry research.

01 Jul 2002·Acta Dermato-Venereologica

Eosinophilic Pustular Folliculitis Induced by Allopurinol and Timepidium Bromide

Letter

Author: Maejima, Hideki ; Mukai, Hideki ; Hikaru, Eto

2. Berti E, Tomasini D, Vermeer MH, Meijer CJ, Alessi E, 9. Ralfkiaer E, Thomsen K, Agdal N, Hou-Jensen K, Wantzin GL. The development of a Ki-1-positive large Willemze R. Primary cutaneous CD8-positive epidermotropic cytotoxic T-cell lymphomas. Am J Pathol 1999; cell non-Hodgkin’s lymphoma in pagetoid reticulosis. Acta Derm Venereol 1989; 69: 206–211. 155: 483–492. 3. Santucci M, Pimpinelli N, Massi D, Kadin ME, Meijer 10. Luther H, Bacharach-Buhles M, Schultz-Ehrenburg U, Altmeyer P. Pagetoide retikulose von typ KetronCJLM, Muller-Hermelink HK, et al. Cytotoxic/natural killer cell cutaneous lymphomas: a clinicopathological Goodman. Hautarzt 1989; 40: 530–535. 11. Lacour JP, Juhlin L, El Baze P, Barety M, Ortonne JP. study of 48 cases from the EORTC cutaneous lymphoma study group. Blood 2002; in press. Disseminated pagetoid reticulosis associated with mycosis fungoides: immunomorphologic study. J Am Acad 4. Krenacs L, Wellmann A, Sorbara L, Himmelmann AW, Bagdi E, JaVe ES, et al. Cytotoxic cell antigen in anaplastic Dermatol 1986; 5: 898–901. 12. Bukulmez G, Atakan N, Taskin M, Bilezikci B, Uner A. large cell lymphomas of Tand null-cell type and Hodgkin’s disease: evidence for distinct cellular origin. Disseminated pagetoid reticulosis: plaques and tumoral lesions occurring simultaneously in the same patient. J Blood 1997; 89: 980–989. 5. Zinzani PL, Baliva G, Magagnoli M, Bendandi M, Eur Acad Dermatol Venereol 2001; 15: 59–61. 13. Slater D, Goepel J, Walker A, Corbett P. Lymphocyte Modugno G, Gherlinzoni F, et al. Gemcitabine treatment in pretreated cutaneous T-cell lymphoma: experience in subsets in pagetoid reticulosis. Br J Dermatol 1984; 11: 244–246. 44 patients. J Clin Oncol 2000; 18: 2603–2606. 6. Haghighi B, Smoller BR, LeBoit PE, Warnke RA, Sander 14. Woringer FR, Kolopp P. Lesion erythemato-squameuse polycyclique de l’avant-bras evoluant depuis 6 ans chez CA, Kohler S. Pagetoid reticulosis (Woringer-Kolopp disease): an immunophenotypic, molecular, and clinicopaun garconnet de 13 ans: histologiquement in ltrat intraepidermique d’apparence tumorale. Ann Dermatol Syph thologic study. Mol Pathol 2000; 13: 502–510. 7. Mielke V, WolV HH, Winzer M, Sterry W. Localized and 1939; 10: 945–948. 15. Willemze R, Kerl H, Sterry W, Berti E, Cerroni L, disseminated pagetoid reticulosis: diagnostic immunophenotypical ndings. Arch Dermatol 1989; 125: 402–406. Chimenti S, et al. EORTC classi cation for primary cutaneous lymphomas: a proposal from the cutaneous 8. Berti E, Cerri A, Cavicchini S, Delia G, Soligo D, Alessi E, et al. Primary cutaneous gamma/delta T-cell lymphoma lymphoma study group of the European Organization for Research and Treatment of Cancer. Blood 1997; 90: presenting as disseminated pagetoid reticulosis. J Invest Dermatol 1991; 96: 718–723. 354–371.

100 Deals associated with Timepidium Bromide Hydrate

External Link

KEGG	Wiki	ATC	Drug Bank
D02535	Timepidium Bromide Hydrate	A03AB19	DBSALT002528

R&D Status

10 top approved records.

to view more data

Indication	Country/Location	Organization	Date
Pain	JP	Nipro ES Pharma KK	08 Dec 1975

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis