Human Blood Coagulation Factor VIII (KM Biologics KK)

A 80-year-old man who underwent right S1 segmentectomy three years ago was pointed out a mass shadow in the right upper lobe by chest computed tomography( CT). Because the mass was suspected of 2nd lung cancer, right upper lobectomy was performed. Air leakage from the chest tube appeared the day after the operation did not improve with the autologous blood patch pleurodesis. Since neither surgery nor invasive pleurodesis was thought to be possible because of the risk of acute respiratory failure due to the severe pulmonary emphysema, the administration of factor was challenged based on the result of its reduced activity. After the administration, the air leaks ceased promptly. Blood coagulation factor supplement may be effective in the treatment for intractable air leaks after lobectomy.