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Last update 08 May 2025

Hydroxymethylnicotinamide

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Hydroxmethylnicotinamide, Hydroxymehtylnicotinamide, Hydroxymethy Imicotinamide

+ [8]

Target-

Action-

Mechanism-

Therapeutic Areas

Digestive System Disorders

Active Indication

Gallbladder Diseases

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC7H8N2O2

InChIKeyJRFKIOFLCXKVOT-UHFFFAOYSA-N

CAS Registry3569-99-1

100 Clinical Results associated with Hydroxymethylnicotinamide

100 Translational Medicine associated with Hydroxymethylnicotinamide

100 Patents (Medical) associated with Hydroxymethylnicotinamide

136

Literatures (Medical) associated with Hydroxymethylnicotinamide

01 Jun 2025·Food Chemistry

Italian White Truffle (Tuber magnatum Pico): Discovery of new molecules through untargeted UHPLC-QTOF-MS analysis

Article

Author: Tiecco, Matteo ; Piatti, Diletta ; Caprioli, Giovanni ; Ricciutelli, Massimo ; Marconi, Riccardo ; Sagratini, Gianni ; Angeloni, Simone ; Alessandroni, Laura

The Italian white truffle (Tuber magnatum Pico) is worldwide recognized as one of the most expensive edible mushrooms. Its chemical characterization has not yet been properly investigated in scientific literature. The aim of this study was to explore, for the first time, the truffle polar metabolic profile using an untargeted approach through UHPLC-ESI-QTOF-MS data-dependent acquisition. The total features list was filtered and molecules were annotated according to the MS spectra correspondence score with a threshold of 60 %. This led to a total of 412 annotated compounds mainly referred to amino acids, B-vitamins, carbohydrates and fatty acids derivatives. A targeted analysis was applied to four annotated molecules never detected in truffle before, being riboflavin, azelaic, 2-isopropylmalic and 3-isopropylmalic acids. Some constituents of the extracts were semi-quantitatively analysed by ¹H NMR spectroscopy. Results place a first brick in white truffle characterization, paving the way towards authenticity biomarkers detection useful in frauds prevention.

15 Oct 2024·Analytical Chemistry

In-Depth Chemical Analysis of the Brain Extracellular Space Using In Vivo Microdialysis with Liquid Chromatography-Tandem Mass Spectrometry

Article

Author: Popov, Pavlo ; Anderson, Brady G. ; Kennedy, Robert T. ; Nwamba, Adanna ; Evans, Charles R. ; Cicali, Amanda R.

Metabolomic analysis of samples acquired in vivo from the brain extracellular space by microdialysis sampling can provide insights into chemical underpinnings of a given brain state and how it changes over time. Small sample volumes and low physiological concentrations have limited the identification of compounds from this compartment, so at present, we have scant knowledge of its composition. As a result, most in vivo measurements have limited depth of analysis. Here, we describe an approach to (1) identify hundreds of compounds in brain dialysate and (2) routinely detect many of these compounds in 5 μL microdialysis samples to enable deep monitoring of brain chemistry in time-resolved studies. Dialysate samples collected over 12 h were concentrated 10-fold and then analyzed using liquid chromatography with iterative tandem mass spectrometry (LC-MS/MS). Using this approach on dialysate from the rat striatum with both reversed-phase and hydrophilic interaction liquid chromatography yielded 479 unique compound identifications. 60% of the identified compounds could be detected in 5 μL of dialysate without further concentration using a single 20 min LC-MS analysis, showing that once identified, most compounds can be detected using small sample volumes and shorter analysis times compatible with routine in vivo monitoring. To detect more neurochemicals, LC-MS analysis of dialysate derivatized with light and isotopically labeled benzoyl chloride was employed. 872 nondegenerate benzoylated features were detected with this approach, including most small-molecule neurotransmitters and several metabolites involved in dopamine metabolism. This strategy allows deeper annotation of the brain extracellular space than previously possible and provides a launching point for defining the chemistry underlying brain states.

06 May 2022·ACS Catalysis

Cobalt-Catalyzed Selective Dearomatization of Pyridines to N–H 1,4-Dihydropyridines

Author: Liu, Lan ; Pang, Maofu ; Xie, Yufang ; Liao, Rong-Zhen ; Tung, Chen-Ho ; Shi, Le-Le ; Wang, Wenguang ; Geng, Tianyi

Catalytic reduction of pyridines to N-H 1,4-dihydropyridines was exceptionally challenging because they are essential intermediates to form tetrahydropyridines.Using a facile dihydrogen source H₃N·BH₃ to activate the pyridine ring in situ, was achieved by selective transfer hydrogenation of nicotinate derivatives to N-H 1,4-dihydropyridines by cobalt-amido cooperative catalysis.The reactions operated smoothly under mild conditions to produce a variety of N-H 1,4-dihydropyridines with high chemo- and regioselectivity.This catalytic method also provides a practical protocol to regenerate Hantzsch analogs after delivery of H₂.

100 Deals associated with Hydroxymethylnicotinamide

External Link

KEGG	Wiki	ATC	Drug Bank
D08051	-	A05AB01	-

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Gallbladder Diseases	-	-	-

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