Delving into the Latest Updates on Hydroxymethylnicotinamide with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Hydroxmethylnicotinamide, Hydroxymehtylnicotinamide, Hydroxymethy Imicotinamide

+ [8]

Target-

Mechanism-

Therapeutic Areas

Digestive System Disorders

Active Indication

Gallbladder Diseases

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure

Molecular FormulaC7H8N2O2

InChIKeyJRFKIOFLCXKVOT-UHFFFAOYSA-N

CAS Registry3569-99-1

AbstractA thin-layer chromatography (TLC)-densitometric method was developed to determine N-(hydroxymethyl)nicotinamide in tablets and basic solutions along with nicotinic acid. Analysis was performed on silica gel F254 plates using chloroformethanol (2 + 3, v/v) mobile phase. The densitometric observations were made at 260 nm. The results showed good precision and accuracy; relative standard deviation was 2.37, and recovery ranged from 97.60 to 100.82. The limit of detection was 0.1 g/spot, while the linearity range was from 0.2 to 1.75 g/spot. Applicability of the newly developed method was tested for determination of N-(hydroxymethyl)nicotinamide in the preparation Cholamid<sup/>. Densitometric measurements were used to evaluate stability of N-(hydroxymethyl)nicotinamide in basic solutions. It was found that decomposition corresponded to first-order reaction kinetics. The computed kinetic and thermodynamic parameters at 30C were as follows: k 0.00675/min, t0,5 1.71 h, t0,1 0.26 h, and Ea 44.75 kJ/mol.

01 Jan 1971·Das Deutsche Gesundheitswesen

[Studies on the antibacterial activity of pyridin-3-carbonic acid oxymethylamide (Nikoform, Bilamid, Felosan) in the treatment of urinary tract infections].

Article

Author: Patsch, R ; Otto-Unger, G ; Höhne, C ; Metzke, H

25 Feb 1960·Das Deutsche Gesundheitswesen

[On the treatment of healthy Salmonella carriers with nikoform].

Article

Author: PASSOLT, D ; STRIETZEL, M

100 Deals associated with Hydroxymethylnicotinamide

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