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Last update 08 May 2025

Etynodiol Diacetate

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

17α-Ethynyl-19-norandrost-4-ene-3β,17-beta-diol diacetate, 17α-Ethynyl-3,17-dihydroxy-4-estrene diacetate, 17α-Ethynyl-4-estrene-3β,17β-diol diacetate

+ [9]

Target

Action

agonists

Mechanism

PR agonists(Progesterone receptor agonists)

Therapeutic Areas

Other Diseases

Active Indication

Contraception

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC24H32O4

InChIKeyONKUMRGIYFNPJW-KIEAKMPYSA-N

CAS Registry297-76-7

Clinical Trials associated with Etynodiol Diacetate

NCT01359163

/ CompletedPhase 1

An Open Label, Randomized, Single Dose, Crossover Pivotal Bioequivalence Study Of Commercial Femulen Tablets Versus Reformulated Femulen Tablets In Healthy Female Subjects

A pivotal study to determine bioequivalence between a the current marketed formulation of Femulen tablets and reformulated Femulen tablets in healthy female subjects.

Start Date01 Jun 2011

Sponsor / Collaborator

Pfizer Inc.

100 Clinical Results associated with Etynodiol Diacetate

100 Translational Medicine associated with Etynodiol Diacetate

100 Patents (Medical) associated with Etynodiol Diacetate

506

Literatures (Medical) associated with Etynodiol Diacetate

01 Apr 2025·Journal of Pharmaceutical Sciences

Optimization of HPLC method for determination of Abraham solvation parameters of pharmaceuticals

Article

Author: Knašienė, Birutė ; Sadaunykas, Audrius ; Sazonovas, Andrius ; Balčiūnas, Simonas ; Naujalis, Evaldas ; Lanevskij, Kiril

Abraham solvation equation (Absolv) is a popular and well-established approach for modeling solute partitioning between phases of different polarity, which finds its applications in both organic chemistry and biomedical fields. Parameters constituting this equation are good quantitative descriptors of solute hydrogen bonding potential that are useful for QSAR modeling of more complex chemical and biological phenomena. Numerous studies dealing with fast determination of Abraham descriptors using HPLC can be found in the literature, but these mostly focus on small un-ionizable industrial and environmental chemicals, whereas experimental data for pharmaceutical molecules are clearly lacking. In the current study we build upon a previously published chromatographic approach, aiming to adapt the method to ionizable drug-like compounds, and optimize it by reducing the number of required HPLC columns. The analysis involves determination of the overall H-bond acidity (A), H-bond basicity (B) and polarity/polarizability (S) descriptors for 62 pharmaceutical molecules with previously unpublished parameter values.

01 Mar 2025·Food Chemistry

Unraveling key non-volatiles responsible for taste differences of Pixian broad bean paste based on sensory analysis and untargeted metabolomics

Article

Author: Wei, Yilan ; Zhou, Wenjing ; Liu, Ping ; Yang, Aiping ; Xu, Min ; Xiang, Qin

Besides aroma, the tastes of Pixian Broad Bean Paste (PBBP) are also important, however, they have not yet been thoroughly elucidated. Therefore, this study employed sensory and untargeted metabolomics approaches to investigate taste characteristics, molecular basis and their metabolic pathways of PBBP from three different manufacturers and two grades. Results showed PBBP was predominantly characterized by strong sour, umami and salty tastes, and significant differences were observed in samples from different manufacturers and grades (p < 0.05), especially higher sourness, saltiness and umami in premium PBBP. Based on non-volatiles, 55 key differential metabolites were identified through orthogonal partial least square discriminant analysis (OPLS-DA, P value<0.05, VIP value>1.0) and Pearson correlation analysis (|ρ| > 0.7). These key differential metabolites responsible for taste differences were metabolized by 36 crucial KEGG pathways (P value<0.05, impact value>0.05). These results could expand our understandings of PBBP taste compounds and their metabolisms, and provide theoretical evidences for further quality improvement.

01 Nov 2024·Cell Reports Physical Science

Photoinduced azidoalkylation of amino acid and peptide derivatives using sulfur hexafluoride as an electron scavenger

Author: Xie, Lan-Gui ; Zhang, Lijiao ; Xu, Dongdong ; Zhao, Yue ; Dong, Bo ; Zhu, Shan ; Gu, Shiyu

Sulfur hexafluoride (SF₆) serves as a protective gas in various industries, notably in high-voltage installations, but it is also recognized as a greenhouse gas with significant global warming potential and a prolonged atm. lifespan.Consequently, stringent regulations govern its emission, necessitating its destruction post use.This study unveils site-specific azidoalkylation of amino acid and peptide derivatives, leveraging SF₆ as an electron scavenger to facilitate electron removal from organic mols. under photoinduced conditions.This approach offers an efficient pathway for introducing a biochem. significant azide group into bioactive mols. and an alternative reaction model for the utilization of SF₆ in organic synthesis.

100 Deals associated with Etynodiol Diacetate

External Link

KEGG	Wiki	ATC	Drug Bank
-	Etynodiol Diacetate	G03DC06	DB00823

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Contraception	-	-	-

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