Delving into the Latest Updates on PD-1Ab21 with Synapse

Overview

Basic Info

Drug Type

Antibody fusion proteins

Synonyms-

Target

IL-21 x PD-1

Action

inhibitors

Mechanism

IL-21 inhibitors(Interleukin-21 inhibitors), PD-1 inhibitors(Programmed cell death protein 1 inhibitors)

Therapeutic Areas

Neoplasms

Active Indication-

Inactive Indication

Neoplasms

Originator Organization

Institute of Biophysics of Chinese Academy of Sciences

Active Organization-

Inactive Organization

Institute of Biophysics of Chinese Academy of Sciences

License Organization-

Drug Highest PhasePendingPreclinical

First Approval Date-

Regulation-

AbstractT cell rejuvenation by PD-1/PD-L1 blockade, despite emerging as a highly promising therapy for advanced cancers, is only beneficial for a minority of treated patients. There is evidence that a lack of efficient T cell activation may be responsible for the failure. Here, we demonstrate that IL-21 can be targeted to tumor-reactive T cells by fusion of IL-21 to anti-PD-1 antibody. To our surprise, the fusion protein PD-1Ab21 promotes the generation of memory stem T cells (TSCM) with enhanced cell proliferation. PD-1Ab21 treatment show potent antitumor effects in established tumor-bearing mice accompanied with an increased frequency of TSCM and robust expansion of tumor-specific CD8+ T cells with a memory phenotype, and is superior to a combination of PD-1 blockade and IL-21 infusion. Therefore, we have developed a potential strategy to improve the therapeutic effects of immune checkpoint blockade by simultaneously targeting cytokines to tumor-reactive T cells.

100 Deals associated with PD-1Ab21

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Neoplasms	Preclinical	China	Institute of Biophysics of Chinese Academy of Sciences	11 Feb 2021

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Clinical Result

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Biosimilar

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