Efficacy and safety of Curcuma longa either alone or in combination with metformin on glycemic status in prediabetes population: A Randomized, double-blinded, double-dummy, placebo-controlled, factorial design trial - NIL

Start Date15 Oct 2025

Sponsor / Collaborator-

CTRI/2025/03/081871

/ Not yet recruitingPhase 2/3

A randomized clinical study to evaluate Karanja patra (Pongamia pinnata Pierre.) in comparison with Haridra (Curcuma longa Linn.) among patients with early stages of Madhumeha (Type 2 Diabetes mellitus). - nill

Start Date12 Jun 2025

Sponsor / Collaborator-

TCTR20250317007

/ Not yet recruitingPhase 1IIT

Skin Evaluation of Turmeric/EGCG Emulgel for Skin Irritation and Sensitization Effects in Healthy Participants

Start Date01 May 2025

Sponsor / Collaborator

Chiang Mai University

100 Clinical Results associated with Turmeric extract

100 Translational Medicine associated with Turmeric extract

100 Patents (Medical) associated with Turmeric extract

228

Literatures (Medical) associated with Turmeric extract

01 Apr 2025·Clinical and Experimental Dental Research

Analgesic Efficacy of Bromelain and Bromelain Plus Turmeric for Pain Control After Orthodontic Separator Placement: A Triple‐Blind Randomized Clinical Trial

Article

Author: Ajami, Shabnam ; Hashemi, Zahra ; Hosseini, Seyyed Hadi ; Babanouri, Neda

ABSTRACT:

Objectives:

This study aimed to compare the analgesic efficacy of Bromelain, Ibuprofen, and Bromelain plus turmeric for pain control after orthodontic separator placement.

Material and Methods:

This triple‐blind randomized clinical trial included 135 patients over the age of 15 who required orthodontic treatment. The patients were randomly assigned to three groups: 400 mg Ibuprofen (Group A), 200 mg Bromelain (ANAHEAL; Group B), and 150 mg Bromelain + 300 mg Turmeric (ANAHEAL PLUS; Group C). The patients took one tablet immediately after the separator was placed. Four separators were placed at the mesial and distal regions of both maxillary first molars. The degree of pain and discomfort was measured using a visual analog scale (VAS) at the following time points: Immediately after the separator placement (T0), 2 h posttreatment (T1), 6 h posttreatment (T2), 24 h posttreatment (T3), and 48 h after separator placement (T4). The data were analyzed using SPSS (version 15.0). Different statistical tests including ANOVA, Tukey's test, and paired t‐test were utilized. p < 0.05 was considered statistically significant.

Results:

Pain scores at 2 h (T1) and 6 h (T2) after separator placement differed significantly among the three groups (p = 0.006 and p = 0.025, respectively), with the Ibuprofen group experiencing significantly higher pain levels than the Bromelain and Bromelain Plus Turmeric groups. At 48 h (T4), a significant difference was observed only in chewing function (p = 0.024), where patients in the Bromelain group reported higher pain scores than those in the Ibuprofen group. Sex had no significant effect on pain perception (P < 0.05).

Conclusions:

Bromelain with or without turmeric might be a useful alternative to Ibuprofen for pain control following orthodontic separator placement.

01 Mar 2025·PHYTOTHERAPY RESEARCH

Curcumin: A Potential Detoxifier Against Chemical and Natural Toxicants

Review

Author: Dhalaria, Rajni ; Sethi, Nidhi ; Upadhyay, Navneet Kumar ; Kimta, Neetika ; Nepovimova, Eugenie ; Manickam, Sivakumar ; Guleria, Shivani ; Dhanjal, Daljeet Singh ; Kumar, Harsh

ABSTRACT:

The human body gets exposed to a variety of toxins intentionally or unintentionally on a regular basis from sources such as air, water, food, and soil. Certain toxins can be synthetic, while some are biological. The toxins affect the various parts of the body by activating numerous pro‐inflammatory markers, like oxidative stresses, that tend to disturb the normal function of the organs ultimately. Nowadays, people use different types of herbal treatments, viz., herbal drinks that contain different spices for detoxification of their bodies. One such example is turmeric, the most commonly available spice in the kitchen and used across all kinds of households. Turmeric contains curcumin, which is a natural polyphenol. Curcumin is a medicinal compound with different biological activities, such as antioxidant, antineoplastic, anti‐inflammatory, and antibacterial. Hence, this review gives a comprehensive insight into the promising potential of curcumin in the detoxification of heavy metals, carbon tetrachloride, drugs, alcohol, acrylamide, mycotoxins, nicotine, and plastics. The review encompasses diverse animal‐based studies portraying curcumin's role in nullifying the different toxic effects in various organs of the body (especially the liver, kidney, testicles, and brain) by enhancing defensive signaling pathways, improving antioxidant enzyme levels, inhibiting pro‐inflammatory markers activities and so on. Furthermore, this review also argues over curcumin's safety assessment for its utilization as a detoxifying agent.

01 Jan 2025·Journal of Rheumatic Diseases

Efficacy of Curcuma longa in relieving pain symptoms of knee osteoarthritis patients: a systematic review and metaanalysis of clinical trials

Article

Author: Parlindungan, Faisal ; Hidayat, Rudy ; Indika, Muhammad Izza ; Mahendra, Arya Ivan ; Efendi, Cristopher ; Nisa, Jihan Izzatun

Objective:

Osteoarthritis (OA), particularly knee OA, affects 24% of adults and is a significant cause of disability. Nonsteroidal anti-inflammatory drugs (NSAIDs) are commonly used but have many adverse effects. Antioxidant and anti-iflammatory properties of Curcuma longa might decrease pain thus improving joint function.

Methods:

This systematic review and meta-analysis evaluated randomized controlled trials (RCTs) on Curcuma longa efficacy for knee OA. We reported mean differences (MD) with 95% confidence interval (CI) for continuous outcomes and evaluated Visual Analog Scale (VAS) for pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) total score over 4 to 6 weeks for treatment effects.

Results:

Ten RCTs with 786 patients were included. Curcuma longa significantly improved VAS for pain than placebo (MD 18.25, 95% CI 7.79 to 28.72, p=0.0006). It was not inferior to NSAIDs in WOMAC total score improvement (MD -11.99, 95% CI -39.21 to 15.23, p=0.39). Both dosages (<1,000 and ≥1,000 mg/day) of Curcuma longa demonstrated similar improvement in VAS for pain compared to placebo (MD 27.02, 95% CI 1.45 to 52.60, p=0.04; MD 21.48, 95% CI 1.78 to 41.18, p=0.03).

Conclusion:

Curcuma longa benefits knee OA pain and function, being more effective than placebo and comparable to NSAIDs. Despite positive results, limitation and heterogeneity of the studies necessitates further research to explore optimal dosages and administration methods of Curcuma longa as therapeutic option for knee OA.

News (Medical) associated with Turmeric extract

05 Aug 2024

·www.drugs.com

Botanicals Like Turmeric, Green Tea Are Harming Americans' Livers

MONDAY, Aug. 5, 2024 -- Botanicals like turmeric , green tea and black cohosh may seem benign, but their overuse is being increasingly linked to liver injury. New research suggests that 7% of U.S. adults are using at least one of the six leading botanicals, the equivalent of 15.6 million people. Many are ending up in hospitals for liver toxicity, researchers report. Because there's almost no regulatory oversight over botanicals, chemical tests of products linked to liver crises "show frequent discrepancies between product labels and detected ingredients," noted a team led by Dr. Alisa Likhitsup . She's an assistant professor of gastroenterology at the University of Michigan in Ann Arbor. The researchers focused on the use of six of the most popular botanicals: Turmeric, green tea extract, the Garcinia cambodgia plant, black cohosh, red yeast rice and ashwagandha. Perusing 2017-2021 data on almost 9,700 adults in a federal health database, they found high rates of botanical use. For example, Likhitsup's group estimated that more than 11 million adults regularly take turmeric supplements, often with the notion that it can ease pain or arthritis . That's not too far below the approximately 14.8 million who take an NSAID pain reliever for much the same reasons. Unfortunately, "multiple randomized clinical trials have failed to demonstrate any efficacy of turmeric-containing products in osteoarthritis," and overdoing it on turmeric has been linked to serious liver toxicity, the researchers said. Likewise, over 3 million adults are estimated to be taking another potential liver toxin, green tea extract, usually to help boost energy and aid in weight loss. But again, "multiple studies have failed to demonstrate any objective evidence of weight loss and sustained improvement in mood or energy levels" with products containing the active ingredients in green tea extract, the Michigan team noted. Other claims, many unfounded, are made for other botanicals: Garcinia cambodgia is touted for weight loss, black cohosh for easing hot flashes and ashwagandha to help build muscle. But Likhitsup and colleagues noted that consumers may be overdosing on botanicals, or getting misled by labels that don't reflect the actual ingredients in their supplements. That may be leading to more users ending up in the ER. According to a national database, cases of liver toxicity linked to botanical use, some severe or even fatal, nearly tripled between 2004 and 2014 -- from 7% of cases to 20%. Use of turmeric, green tea extract, Garcinia cambodgia were often implicated. Another study found such cases rising from 12.5% of liver toxicity cases in 2007 to 21.1% by 2015. Who's using these botanicals? According to the new study, the most common consumer is an older (average age about 52) white (75% of users) female (57%), who was typically well-off. People taking botanicals were more likely to be battling some kind of chronic illness, such as arthritis, thyroid disorders or cancer, compared to folks not using the supplements. In two-thirds of cases, people took a botanical while also taking a prescription medicine, the study found. Because of the danger of drug interactions and the threat to liver health, it's crucial that botanical users inform their doctors, Likhitsup's group said. When botanicals are overused, the damage to the liver "can not only be severe, leading to hepatocellular [liver] injury with jaundice, but also fatal, leading to death or liver transplantation," the research team warned. A prior study found that the number of liver transplants required due to botanical overuse has jumped by 70% between 2009 and 2020. The Michigan team believe better regulation and oversight are needed to protect consumers. "Considering widespread and growing popularity of botanical products, we urge government authorities to consider increasing the regulatory oversight on how botanicals are produced, marketed, tested and monitored in the general population," they wrote. The study was published Aug. 5 in the journal JAMA Network Open. Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

29 Jul 2024

·www.prnewswire.com

Ayurveda Women's Health Market to Reach US$ 7.2 Billion by 2034, Driven by Growing Prevalence of Women's Health Issues and Enhanced Focus on Gut Health | TMR

The expansion of the Ayurvedic women's health industry is mostly due to the rise in the prevalence of women's health issues and the necessity to treat hormonal imbalances. WILMINGTON, Del., July 29, 2024 /PRNewswire/ -- The Ayurveda women's health market was projected to attain US$ 3.6 billion in 2023. It is likely to garner a 6.3% CAGR from 2024 to 2034, and by 2034, the market is expected to attain US$ 7.2 billion. Yoga poses, or asanas, are another aspect of Ayurvedic women's health practices that can help with conditions like menstrual cramps and back pain. They benefit women of all ages, but especially pregnant women, by improving posture, strength, and flexibility. Stress-relieving herbal tea brewed with chamomile and peppermint can be consumed. Fenugreek seeds can assist in increasing milk production, which is beneficial for nursing moms. As a result, the market value of Ayurveda for women's health is increasing due to growing knowledge of its benefits. Request for sample PDF copy of report: Key Findings of Market Report Ayurveda includes self-massage, or "Abhyanga," among its practices. The heated oil used here promotes better blood circulation and calms the nervous system. This is especially beneficial for menopausal ladies. The preservation of healthy skin and joint lubrication are the other benefits. Herbs like ashwagandha and asparagus are suggested in addition to meditation to promote hormonal balance. Turmeric and ginger can aid in the battle against inflammation and dyspepsia. Regarding the same, there are several Ayurvedic pills accessible. But before using Ayurvedic treatments, ladies should make sure they know what's in them. For example, certain Ayurvedic items may include lead or mercury, both of which are harmful to health. Furthermore, there are misconceptions about pregnant women taking Ayurvedic medications. These elements could eventually limit the market for Ayurvedic women's health. Market Trends for Ayurveda Women's Health Hormonal imbalances may lead to a wide range of health issues, including mood changes, weight gain, and perhaps even infertility. Ayurveda provides a comprehensive method for naturally achieving hormone balance. Hormonal imbalances can result from certain medical disorders, such as heavy menstrual bleeding, poor diet, and stress. According to Ayurveda, using herbs like ashwagandha, guduchi, and shatavari is beneficial for women's health. It suggests using panchakarma to assist the body rid itself of toxins, which can help balance hormones. Breathing techniques and meditation are also advised. Regular oil massage with Ayurvedic medicinal oils can assist with hormone balance, stress reduction, and improved circulation. The WHO estimates that 8–13% of women in the globe who are of reproductive age have PCOS. Thus, the need to adequately address the hormonal imbalance that is the primary cause of PCOS is driving the expansion of the Ayurvedic women's health industry. Ayurveda Women's Health Market Report Scope: Unlock Growth Potential in Your Industry! Download PDF Brochure: Global Market for Ayurveda Women's Health: Regional Outlook Various reasons propel the Ayurveda women's health market growth throughout the regions. These are: Asia Pacific held the greatest proportion of the Ayurvedic women's health market in 2023, according to the most recent research on the industry. Throughout the projection period, the area is anticipated to remain at the forefront in this respect. This is attributable to several awareness-raising initiatives on the use of Ayurveda for women's health treatments carried out by both governmental and non-governmental organizations in nations like China and India. The main players are also creating women's Ayurvedic food. Take Deep Ayurveda Healthcare Pvt., for example. Ltd. has introduced NariPunch, a superfood Ayurvedic for the wellness of women. Ayurveda Women's Health Market: Key Players By educating women in low- and middle-income areas about the value of their health, the major participants in the Ayurvedic women's health industry hope to increase the size of their clientele. The following companies are well-known participants in the ayurveda women's health market: The Himalaya Drug Company Dabur Patanjali Ayurved Limited Baidyanath Group Hamdard Laboratories (India) Vicco Laboratories Charak Pharma Pvt. Ltd. Sri Sri Tattva Zandu Pharma Works Ltd. Arya Vaidya Pharmacy (Coimbatore) Ltd. Key Developments Ayufy released its mobile app on the Play Store and App Store in February 2024. There are fifty Ayurvedic physicians on board. According to the firm, it is the first Ayurvedic start-up in India focused on helping women of all ages with their gynecological problems. Global Ayurveda Women's Health Market Segmentation Product Type - Herbal Supplements - Ayurvedic Medicines - Herbal Tea - Ayurvedic Oils and Balms Indication - Menstrual Disorders - Menopause Symptoms - Fertility Issues - Pregnancy Care - Others (Postpartum Care, etc.) Age Group - Adolescents - Adults - Elderly Women Distribution Channel - Online Retail - Specialty Stores - Pharmacies - Direct Sales - Others By Region - North America - Latin America - Europe - Asia Pacific - Middle East & Africa Buy this Premium Research Report: More Trending Reports by Transparency Market Research – Consumer Genomics Market - The global consumer genomics market was estimated to have acquired US$ 2.4 billion in 2021. It is anticipated to register a 22.3% CAGR from 2022 to 2032 and by 2032, the market is likely to gain US$ 21.2 billion. Acute Migraine Treatment Market - The global market for acute migraine treatment was estimated to be worth a market valuation of around US$ 2.1 billion in 2021. The market is anticipated to advance with a booming 15.1% CAGR from 2023 to 2031 and by 2031, the market is likely to gain US$ 7.9 billion. Biological Imaging Reagents Market is expected to grow at a CAGR of 5.4% from 2023 to 2031 and reach US$ 26.9 Bn by the end of 2031 About Transparency Market Research Transparency Market Research, a global market research company registered at Wilmington, Delaware, United States, provides custom research and consulting services. Our exclusive blend of quantitative forecasting and trends analysis provides forward-looking insights for thousands of decision makers. Our experienced team of Analysts, Researchers, and Consultants use proprietary data sources and various tools & techniques to gather and analyses information. Our data repository is continuously updated and revised by a team of research experts, so that it always reflects the latest trends and information. With a broad research and analysis capability, Transparency Market Research employs rigorous primary and secondary research techniques in developing distinctive data sets and research material for business reports. Contact: Transparency Market Research Inc. CORPORATE HEADQUARTER DOWNTOWN, 1000 N. West Street, Suite 1200, Wilmington, Delaware 19801 USA Tel: +1-518-618-1030 USA – Canada Toll Free: 866-552-3453 Website: Email: [email protected] Follow Us: LinkedIn | Twitter | Blog | YouTube Logo: SOURCE Transparency Market Research

Acquisition

12 Feb 2024

·www.prnewswire.com

Immune Support Matters: OjasTee Redefines Wellness with its Immune-Boosting Spice-Based Products

BERKELEY, Calif., Feb. 12, 2024 /PRNewswire/ -- OjasTee LLC, a California-based company founded in 2020 by retired physician Dr. Rajah Sekaran and former biotech scientist Bob Milley, is making waves in the wellness industry with its innovative approach to immune health. Inspired by the challenges posed by the COVID-19 and its variants, OjasTee is on a mission to provide wellness products. Continue Reading Golden Latte TURMERIC Mix (200 Grams) OjasTee products Spices Are an Effective Way to Combat Inflammation and Boost Immunity The 7-spice blend, carefully curated with ingredients like Turmeric, Cumin, Cinnamon, Ginger, Nutmeg and Pepper aims to support the immune system through its potent antioxidant and anti-inflammatory qualities. Pepper in OjasTee's products promotes absorption of Turmeric 2000%. A Spice-Based Journey to Health OjasTee encourages the consumption of these spices as Dietary Supplement in various forms, including Teas, Golden Latte, Seasonings for all cuisines, and Rubs for fish, meat, and vegetables. Quality Assurance and Certification All spices, teas, herbs, and ingredients undergo rigorous testing by suppliers and co-packers. The company's dedication to quality is further emphasized by its certification from the Western Regional Minority Supplier Development Council (NMSDC), ensuring that OjasTee meets the standards for promoting HEALTH and WELLNESS. Merieux NutriSciences labs certified the presence of Curcuminoid, the active component in Turmeric and a major ingredient in all of OjasTee's products. Turmeric being antioxidant by itself converts inactive antioxidants from other foods to active antioxidants as well. Meet the Visionary Behind OjasTee Dr. Rajah Sekaran, the founder, brings a wealth of experience as a retired physician. His extensive background in medicine and philosophy led to the creation of OjasTee's spice blend. OjasTee's Philosophical Approach Dr. Sekaran's commitment to health is reflected in his recent publications, "Tennis Made Easy and Yoga of Mind and Body" and "Beyond Mind–The Next Step in Human Evolution," which outlines the Feedback Theory. This theory emphasizes the interconnectedness of internal and external environments, highlighting the need for a balanced lifestyle to maintain optimal health. Support Your Immune Health OjasTee advocates lifestyle changes at both the mental and physical levels. The company encourages kindness with good intentions and stress management at the mental level. At the physical level, OjasTee promotes a balanced diet with adequate exercise, emphasizing the inclusion of spices and herbs for their antioxidant and anti-inflammatory properties. For more information about OjasTee and its transformative products, visit . Media Contact: M Rajah Sekaran [email protected] 510-496-1077 SOURCE OjasTee

100 Deals associated with Turmeric extract

R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Primary osteoarthritis of knee NOS	Phase 3	Thailand	Mahidol University	01 Dec 2008

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASN2021	Not Applicable	Nephrolithiasis, Calcium Oxalate	-	Turmeric 2g daily	ydoykxhpbz(qgbzbadigj) = sxcbodydkx qczebabnzb (cllqhnbuae ) View more	Negative	27 Oct 2021

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