Delving into the Latest Updates on Prajmalium Bitartrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Prajmalium, Prajmalium bitartrate (INN), GT-1012

+ [3]

Target-

Mechanism-

Therapeutic Areas

Cardiovascular Diseases

Active Indication

Arrhythmias, Cardiac

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Login to view timeline

Structure

Molecular FormulaC27H38N2O8

InChIKeyVZAUGYDMVQSQAO-UVVABDOQSA-M

CAS Registry2589-47-1

Prajmalium rarely causes idiosyncratic liver injury. Author describes the case of cholestatic hepatitis occurring in three weeks after cessation of short-term treatment with prajmalium. Eighteen months later, despite of good general status, physical and biochemical features of cholestasis were present. Pathologic examination of liver biopsy specimen revealed the chronic intracellular cholestasis with lymphocytic infiltration. Presented case indicate that even short-term treatment with potentially weekly hepatotoxic drug may cause the long-term intrahepatic cholestasis.

01 Aug 2001·Medizinische Klinik (Munich, Germany : 1983)

Das Brugada-Syndrom

Article

Author: Fischer, S ; Kettner, W ; Reinhold, S

BACKGROUND:

A high take-off descending ST segment associated with right bundle branch block is the typical ECG criterion of the Brugada-Brugada syndrome. It leads to ventricular fibrillation or syncopes in case of a familiar disposition.

CASE REPORT:

We describe a 56-year-old man in whom oral prajmalium bitartrate therapy previously prescribed for symptomatic ventricular extrasystoles unmasked an electrographic pattern characteristic of a Brugada syndrome. After the ongoing invasive diagnostic a right ventricular dysplasia in the same case is possible. The patient was treated with an ICD pacemaker.

01 Jul 2000·Die Pharmazie

Article

Author: Hinse, C ; Stöckigt, J

Prajmaline, the semisynthetic propyl derivative of ajmaline, shows a much better bioavailability when compared with the Rauvolfia alkaloid ajmaline. Early NMR and IR-studies, fluorescence spectroscopic investigations and extraction experiments combined with ion-pair chromatography proved the thesis of a tautomeric equilibrium between an aldehyde-amine and a quaternary carbinol-ammonium component. The aim of this study was to confirm this thesis by HPLC-separation and by structure-determination of both tautomeric compounds.

100 Deals associated with Prajmalium Bitartrate

Login to view more data