Last update 24 Jan 2026

AS-703988

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
AS703988, AS703988/MSC2015103B, MSC 2015103B
+ [2]
Target
MEK
Action
inhibitors
Mechanism
MEK inhibitors(STE7 family inhibitors)
Therapeutic Areas
Neoplasms
Active Indication-
Inactive Indication
Advanced Malignant Solid Neoplasm
Originator Organization
Merck Serono SA
Active Organization-
Inactive Organization
EMD Serono, Inc.EMD Serono, Inc.
License Organization
Day One Biopharmaceuticals, Inc.Merck KGaA
Drug Highest PhaseDiscontinuedPhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with AS-703988
NCT01453387
/ TerminatedPhase 1
A Phase I Dose-Escalation First-In-Human Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of the Oral MEK Inhibitor MSC2015103B Administered With Two Different Treatment Schedules in Subjects With Advanced Solid Tumors
100 Clinical Results associated with AS-703988
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100 Translational Medicine associated with AS-703988
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100 Patents (Medical) associated with AS-703988
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100 Deals associated with AS-703988
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 1
United States
EMD Serono, Inc.EMD Serono, Inc.
01 Sep 2011
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Core Patent

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Clinical Trial

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Approval

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Regulation

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