Delving into the Latest Updates on SBT-020 with Synapse

Overview

Basic Info

Drug Type

Synthetic peptide

Synonyms

SS-20-Stealth BioTherapeutics

+ [1]

Target-

Mechanism-

Therapeutic Areas

Nervous System DiseasesCongenital DisordersOther Diseases

Active Indication

Huntington Disease

Inactive Indication-

Originator Organization

Stealth BioTherapeutics Corp.

Active Organization

Stealth BioTherapeutics Corp.

Inactive Organization-

Drug Highest PhasePhase 2

First Approval Date-

Regulation-

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Structure

Molecular FormulaC30H45N9O4

InChIKeyUEADSLOWOVCODN-JBXUNAHCSA-N

CAS Registry736992-19-1

Gene Sequence

Sequence Code 144486

Author: Hughes, Meghan C. ; Perry, Christopher Gr ; Turnbull, Patrick C ; Hawke, Thomas J ; Backx, Peter H ; Backx, Peter H. ; Simpson, Jeremy A ; Ramos, Sofhia V ; Polidovitch, Nazari N. ; Ramos, Sofhia V. ; Brahmbhatt, Aditya N. ; Schlattner, Uwe ; Polidovitch, Nazari N ; Hawke, Thomas J. ; Garibotti, Madison C. ; Perry, Christopher GR. ; Simpson, Jeremy A. ; Turnbull, Patrick C. ; Garibotti, Madison C ; Brahmbhatt, Aditya N ; Hughes, Meghan C

01 Apr 2023·Chemical Biology & Drug Design

Protective effect of a mitochondria‐targeting peptide against paclitaxel‐induced peripheral neuropathy

Letter

Author: Schiller, Peter W. ; Itoh, Kensaku ; Shimoyama, Megumi ; Toyama, Satoshi

AbstractChemotherapy‐induced peripheral neuropathy (CIPN) is a major side effect of several anticancer agents including paclitaxel, a chemotherapeutic drug widely used in cancer treatment. CIPN deteriorates patients' quality of life and compromises cancer treatment. Dysfunction or injury of mitochondria has been suggested to be involved in the induction of this neuropathy. SS‐20 is a tetrapeptide that targets mitochondria and restores mitochondrial bioenergetics. This study was aimed to examine the protective effect of SS‐20 against paclitaxel‐induced peripheral neuropathy using a murine model. Repeated administration of paclitaxel to mice induced peripheral neuropathy as demonstrated by the presence of mechanical allodynia and the loss of intraepidermal nerve fibers in the hind paw. Concomitant administration of SS‐20 protected against the development of the neuropathy. Our results suggest that SS‐20 may be a drug candidate for the prevention of CIPN.

28 Sep 2021·Toxicological SciencesQ2 · MEDICINE

A Sulfonyl Azide-Based Sulfide Scavenger Rescues Mice from Lethal Hydrogen Sulfide Intoxication

Q2 · MEDICINE

Article

Author: Ikeda, Takamitsu ; Marutani, Eizo ; Ni, Xiang ; Ichinose, Fumito ; Xian, Ming ; Hanaoka, Kenjiro ; Miyazaki, Yusuke

AbstractExposure to hydrogen sulfide (H2S) can cause neurotoxicity and cardiopulmonary arrest. Resuscitating victims of sulfide intoxication is extremely difficult, and survivors often exhibit persistent neurological deficits. However, no specific antidote is available for sulfide intoxication. The objective of this study was to examine whether administration of a sulfonyl azide-based sulfide-specific scavenger, SS20, would rescue mice in models of H2S intoxication: ongoing exposure and post-cardiopulmonary arrest. In the ongoing exposure model, SS20 (1250 µmol/kg) or vehicle was administered to awake CD-1 mice intraperitoneally at 10 min after breathing 790 ppm of H2S followed by another 30 min of H2S inhalation. Effects of SS20 on survival were assessed. In the post-cardiopulmonary arrest model, cardiopulmonary arrest was induced by an intraperitoneal administration of sodium sulfide nonahydrate (125 mg/kg) in anesthetized mice. After 1 min of cardiopulmonary arrest, mice were resuscitated with intravenous administration of SS20 (250 µmol/kg) or vehicle. Effects of SS20 on survival, neurological outcomes, and plasma H2S levels were evaluated. Administration of SS20 during ongoing H2S inhalation improved 24-h survival (6/6 [100%] in SS20 vs 1/6 [17%] in vehicle; p = .0043). Post-arrest administration of SS20 improved 7-day survival (4/10 [40%] in SS20 vs 0/10 [0%] in vehicle; p = .0038) and neurological outcomes after resuscitation. SS20 decreased plasma H2S levels to pre-arrest baseline immediately after reperfusion and shortened the time to return of spontaneous circulation and respiration. These results suggest that SS20 is an effective antidote against lethal H2S intoxication, even when administered after cardiopulmonary arrest.

100 Deals associated with SBT-020

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