Delving into the Latest Updates on Recombined HSV1,HSV2 Vaccine(Vaxiit) with Synapse

Overview

Basic Info

Drug Type

Combination vaccine, Prophylactic vaccine

Synonyms

HSV 1 and 2 Vaccine,Replication-defective

Target-

Mechanism

Immunostimulants

Therapeutic Areas

Infectious DiseasesSkin and Musculoskeletal Diseases

Active Indication

Herpes Simplex

Inactive Indication-

Originator Organization

Vaxxit SRL

Active Organization

Vaxxit SRL

Inactive Organization-

Drug Highest PhasePreclinical

First Approval Date-

Regulation-

Author: Oestreich, Makinna ; Sawyer, Jaymie R ; Garabedian, Doreen ; Cohen, Jeffrey I ; Haynes, Winston A ; Dowdell, Kennichi ; Hunsberger, Sally ; Bozekowski, Joel ; Lumbard, Keith ; Vogel, Joshua S ; Wang, Kening ; Reifert, Jack ; Jegaskanda, Sinthujan ; Shon, John C ; Ali, Mir A ; Nguyen, Hanh ; Pietz, Harlan L ; Dropulic, Lesia ; Daugherty, Patrick S

AbstractPrevious herpes simplex virus type 2 (HSV-2) vaccines have not prevented genital herpes. Concerns have been raised about the choice of antigen, the type of antibody induced by the vaccine, and whether antibody is present in the genital tract where infection occurs. We reported results of a trial of an HSV-2 replication-defective vaccine, HSV529, that induced serum neutralizing antibody responses in 78% of HSV-1–/HSV-2– vaccine recipients. Here we show that HSV-1–/HSV-2– vaccine recipients developed antibodies to epitopes of several viral proteins; however, fewer antibody epitopes were detected in vaccine recipients compared with naturally infected persons. HSV529 induced antibodies that mediated HSV-2–specific natural killer (NK) cell activation. Depletion of glycoprotein D (gD)–binding antibody from sera reduced neutralizing titers by 62% and NK cell activation by 81%. HSV-2 gD antibody was detected in cervicovaginal fluid at about one-third the level of that in serum. A vaccine that induces potent serum antibodies transported to the genital tract might reduce HSV genital infection.

100 Deals associated with Recombined HSV1,HSV2 Vaccine(Vaxiit)

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