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Last update 08 May 2025

Tisopurine

Last update 08 May 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Tisopurine (INN), Exuracid

Target-

Action-

Mechanism-

Therapeutic Areas

Congenital DisordersEndocrinology and Metabolic DiseaseSkin and Musculoskeletal Diseases+ [1]

Active Indication

Gout

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

License Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC5H4N4S

InChIKeyPYAOPMWCFSVFOT-UHFFFAOYSA-N

CAS Registry5334-23-6

100 Clinical Results associated with Tisopurine

100 Translational Medicine associated with Tisopurine

100 Patents (Medical) associated with Tisopurine

119

Literatures (Medical) associated with Tisopurine

01 Dec 2024·Chemical Papers

Allopurinol, oxypurinol, and thiopurinol expired drugs as corrosion inhibitors toward Al (111) surface: a DFT and FPMD simulation study

Author: Mohamed, Lamiaa A. ; Ibrahim, Mahmoud A. A. ; Rady, Al-shimaa S. M. ; Shoeib, Tamer ; Mahmoud, Amna H. M. ; El-Tayeb, Mohamed A. ; Rabee, Abdallah I. M.

Abstract: By means of d. functional theory and first-principle mol. dynamics (FPMD) simulations, the corrosion inhibition potential of allopurinol (Allo), oxypurinol (Oxy), and thiopurinol (Thio) expired drugs toward the aluminum (Al) (111) surface was thoroughly examinedESP maps and FMOs anal. indicated the electron-donating nature of the studied drugs.From global reactivity descriptors, the potential of the Allo, Oxy, and Thio drugs in gas and aqueous phases as corrosion inhibitors was confirmed.Thio drug showed lower IP and higher EA values than the other investigated drugs, illustrating its higher reactivity.Further, the lowest value of n and the highest value of σ were found for the Thio drug, indicating its high potential as a corrosion inhibitor.Employing FPMD simulations, the most stable configurations of the drug•••Al (111) complexes were determined, and the corresponding interaction and binding energies were estimatedAccording to the energetic affirmations, the Thio drug demonstrated the largest affinity to inhibit the Al (111) surface with an interaction energy (E_int) value of - 25.12 kcal/mol.The findings of the charge transfer (Q_t) were in line with the E_int, in which the Q_t of the drug•••Al (111) complexes decreased in the order Thio••• > Allo••• > Oxy•••Al (111) with values of - 0.5119, - 0.2737, and - 0.2471 e, resp.The obtained results would provide fundamental insights into the promising application of Allo, Oxy, and Thio expired drugs as corrosion inhibitors, especially for aluminum surface.Graphical abstract:

06 Nov 2020·Organic LettersQ1 · CHEMISTRY

Chemoselective Perfluoromethylation of Thio- and Selenoamides

Q1 · CHEMISTRY

Article

Author: Xu, Xianhong ; Xu, Tao ; Zhang, Jianyu

A chemo- and regioselective perfluoromethylation using thioamides/selenoamides (prepared one step from corresponding lactams) as starting materials has been discovered. The reaction demonstrated complementary chemoselectivity to the C-H trifluoromethylation of (hetero)arenes as well as remarkable functional group compatibility especially toward radical sensitive olefin-, alkyne-, and arylhalide-bearing substrates. The examples of perfluorothio-/selenolated drug molecules indicated application potential of this strategy in drug modification and drug-analogue preparation.

01 Nov 2019·Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular BiologyQ3 · BIOLOGY

Estradiol-17β regulates the expression of insulin-like growth factors 1 and 2 via estradiol receptors in spotted scat (Scatophagus argus)

Q3 · BIOLOGY

Article

Author: Zhang, Ke-Wei ; Chen, Hua-Pu ; Wu, Tian-Li ; Jiang, Dong-Neng ; Li, Guang-Li ; Zhang, Yong ; Deng, Si-Ping ; Zhu, Chun-Hua

Insulin-like growth factors (Igf1 and Igf2) play a key role in growth and development of vertebrates. In mammals, the expression of IGFs is regulated by estradiol-17β (E₂) via estrogen receptors (ESRs). The expression of igfs can also be regulated by E₂ in fish, while comparative study of this is still lacking. The present study examined tissue distribution of igfs and hepatic expression of igfs and esrs during gonad development in Scatophagus argus by real-time PCR. Serum E₂ concentration was measured by enzyme-linked immunosorbent assay (ELISA). The hepatic expression of igfs and esrs at gonadal phase III, incubated with either E₂ (0.1, 1 or 10 μM) alone or in combination with estrogen receptor antagonists-fulvestrant, MPP or PHTPP, was measured. igf1 and igf2 expressed highest in liver of both sexes. Igf1, esr1 and esr2b expressions and serum E₂ concentration increased, while igf2 and esr2a expressions decreased, during ovary development. Igfs and esrs expressions increased while serum E₂ concentration maintained low during testis development. In females, E₂ incubation enhanced the expressions of igf1 and esr1 but inhibited that of igf2 and esr2a. Both fulvestrant and MPP inhibited up-regulation effect of E₂ on igf1 and esr1. Fulvestrant enhanced down-regulation effect of E₂ on igf2 and esr2a, but MPP conversely. In males, E₂ incubation enhanced the expressions of igfs, esr1 and esr2a. Fulvestrant and MPP inhibited up-regulation effect of E₂ on igfs and esr1. PHTPP inhibited igf1 and esr2 expressions in both sexes. Our results indicated that the expression of igfs is regulated by E₂ via Esrs in S. argus.

100 Deals associated with Tisopurine

External Link

KEGG	Wiki	ATC	Drug Bank
D07278	Tisopurine	M04AA02	DB13807

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Gout	-	-	-

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