[Translation] A multicenter, parallel, randomized, placebo-controlled phase II clinical trial evaluating the efficacy and safety of injectable YD0743 in the treatment of sepsis-associated acute respiratory distress syndrome.
主要目的:评价注射用YD0743治疗脓毒症相关ARDS患者的临床初步有效性;
次要目的:1)评价注射用YD0743治疗脓毒症相关ARDS患者的安全性;2)评价注射用YD0743治疗脓毒症相关ARDS患者的炎症指标变化;3)评价注射用YD0743治疗脓毒症相关ARDS患者的药代动力学(PK)特征。
[Translation] Primary objective: To evaluate the preliminary clinical efficacy of YD0743 for injection in patients with sepsis-related ARDS; Secondary objectives: 1) To evaluate the safety of YD0743 for injection in patients with sepsis-related ARDS; 2) To evaluate changes in inflammatory markers in patients with sepsis-related ARDS treated with YD0743 for injection; 3) To evaluate the pharmacokinetic (PK) characteristics of YD0743 for injection in patients with sepsis-related ARDS.