Delving into the Latest Updates on ZP-001 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Target-

Action-

Mechanism-

Therapeutic Areas

Nervous System DiseasesSkin and Musculoskeletal Diseases

Active Indication-

Inactive Indication

Contracture

Originator Organization

Zambon Company SpA

Active Organization-

Inactive Organization

Zambon Company SpA

License Organization-

Drug Highest PhasePendingDiscovery

First Approval Date-

Regulation-

cf. CA 62, 8420a.Adsorption of alkali metal ions was studied on phenol-H₂CO resin (Duolite C-3, 10-50 mesh), sulfonated polystyrene-divinylbenzene resin (Dowex 50-X8, -400 mesh, H⁺ form), and Zr phosphate (Bio-Rad ZP-1, 100-200 mesh) from aqueous and aqueous-methanolic HCl.Adsorbability on Dowex 50-X8 was larger in 80% MeOH than in aqueous solutionsThe ratios of adsorbabilities of K, Rb, and Cs on Dowex 50-X8 decreased slightly and that of Li, Na, and K increased with increasing MeOH concentrationThe ratios of adsorbabilities of Li, Na, and K are the same for Duolite C-3 and Dowex 50-X8.The ratios of adsorbabilities of K, Rb, and Cs are larger for Duolite C-3.The ratios of adsorbabilities of Li, Na, and K on Duolite C-3 in 80% MeOH solution were about the same as for Dowex 50-X8.The ratios of adsorbabilities of K, Rb, Cs, and Fr in 80% MeOH were much larger with Duolite C-3 than with Dowex 50-X8.With both Dowex 50-X8 and Duolite C-3, separation of Li⁺ from Na⁺ and Na⁺ from K⁺ and other alkali metals is improved through use of HCl-H₂O-MeOH mixturesBio-Rad ZP-1 was useful in separating Rb from K, especially when Rb: K ratio is small.

100 Deals associated with ZP-001

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