F ROM the t ime of their earliest descript ion in the late 18th century , ~ meningiomas have been considered indolent relatively benign tumors which, when their location is favorable, can be completely removed. Yet Simpson 2~ repor ted recurrences in ~ 1 ~ of ~65 surgical cases; half of these were in pat ients in whom radical removal had been considered complete. He emphasized the invasive proper t ies of these tumors, including limited infi l tration of the brain in 4 % of his cases, and alluded to two examples of definite mal ignancy. This propensi ty for vigorous act ivi ty which m a y progress to f rank mal ignancy was recognized as long ago as 18582 In 19~7, Craig 6 reviewed 56 cases of intracranial meningiomas, and found 11 mal ignan t variants. Cushing and E i senhard t described six examples in their series of 313 meningiomas. 7 Turner , et al., 26 in a s tudy of 370 intracranial meningeal tumors , found 36 wi th mal ignant characteristics. Moreover, extracranial n le tas tases of meningiomas may o c c u r . 2'7'I0'11'13'14'16'17'21-23'25 ~nteresting]y enough, in some of these cases the microscopic appea rance of bo th the p r ima ry and me tas t a t i c t um or s was tha t of a benign mening ioma? '11'~5'26 Still another mal ignant var ian t of the same fundamenta l pathological process is the diffuse, generalized, meningeal meningiomatosis . 4'5' s,~s,27 Our report concerns the sol i tary intracranial meningioma which, because of its microscopic appearance t aken in conjunction with its gross character is t ics and behavior, is deemed to be mal ignant .

Scientific Reports

The effect of a startle-eliciting device on the foraging success of individual harbor seals (Phoca vitulina)

Article

Author: Acevedo-Gutiérrez, Alejandro ; Ashe, Erin ; Janik, Vincent M ; McKeegan, Kathleen A ; Reiss, Stephanie ; Goetz, Thomas ; Clayton, Kate ; Mendez-Bye, Andrea ; Williams, Rob ; Zinkgraf, Matthew

AbstractPinniped predation on commercially and ecologically important prey has been a source of conflict for centuries. In the Salish Sea, harbor seals (Phoca vitulina) are suspected of impeding the recovery of culturally and ecologically critical Pacific salmon (Oncorhynchus spp.). In Fall 2020, a novel deterrent called Targeted Acoustic Startle Technology (TAST) was deployed at Whatcom Creek to deter harbor seals from preying on fall runs of hatchery chum (O. keta) and Chinook (O. tshawytscha) salmon in Bellingham, Washington, USA. Field observations were conducted in 2020 to compare the presence and foraging success of individual harbor seals across sound exposure (TAST-on) and control (TAST-off) conditions. Observations conducted the previous (2019) and following (2021) years were used to compare the effects observed in 2020 to two control years. Using photo-identification, individual seals were associated with foraging successes across all 3 years of the study. Generalized linear mixed models showed a significant 45.6% reduction in the duration (min) individuals remained at the creek with TAST on, and a significant 43.8% reduction in the overall foraging success of individuals. However, the observed effect of TAST varied across individual seals. Seals that were observed regularly within one season were more likely to return the year after, regardless of TAST treatment. Generalized linear models showed interannual variation in the number of seals present and salmon consumed. However, the effect of TAST in 2020 was greater than the observed variation across years. Our analyses suggest TAST can be an effective tool for managing pinniped predation, although alternate strategies such as deploying TAST longer-term and using multi-unit setups to increase coverage could help strengthen its effects. Future studies should further examine the individual variability found in this study.

100 Deals associated with EU-205

R&D Status

10 top R&D records.

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Solid tumor	Preclinical	South Korea	Eutilex Co., Ltd.	19 Aug 2024

Clinical Result

Indication

Phase

Evaluation

View All Results

Translational Medicine

Boost your research with our translational medicine data.

view full example data

Deal

Boost your decision using our deal data.

view full example data

Core Patent

Boost your research with our Core Patent data.

view full example data

Clinical Trial

Identify the latest clinical trials across global registries.

view full example data

Approval

Accelerate your research with the latest regulatory approval information.

view full example data

Regulation

Understand key drug designations in just a few clicks with Synapse.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis


No Data

EU-205

Overview

Basic Info

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation