Last update 02 Aug 2025

SYN608

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms-
Target
PARG
Action
inhibitors
Mechanism
PARG inhibitors(Poly(ADP-ribose) glycohydrolase inhibitors)
Therapeutic Areas
NeoplasmsEndocrinology and Metabolic DiseaseSkin and Musculoskeletal Diseases+ [1]
Active Indication
BRCA mutation positive Breast CancerHRD positive cancerLocally Advanced Malignant Solid Neoplasm+ [2]
Inactive Indication-
Originator Organization
SynRx Therapeutics Co., Ltd.
Active Organization
SynRx Therapeutics Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1
First Approval Date-
Regulation-
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Related

1
Clinical Trials associated with SYN608
NCT07088588
/ Not yet recruitingPhase 1
A First-in-Human Phase 1 Study to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of SYN608, a Poly ADP-ribose Glycohydrolase (PARG) Inhibitor in Patients With Locally Advanced or Metastatic Solid Tumors
100 Clinical Results associated with SYN608
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100 Translational Medicine associated with SYN608
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100 Patents (Medical) associated with SYN608
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100 Deals associated with SYN608
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
BRCA mutation positive Breast CancerPhase 1
China
SynRx Therapeutics Co., Ltd.
31 Jul 2025
HRD positive cancerPhase 1
China
SynRx Therapeutics Co., Ltd.
31 Jul 2025
Locally Advanced Malignant Solid NeoplasmPhase 1
China
SynRx Therapeutics Co., Ltd.
31 Jul 2025
Metastatic Solid TumorPhase 1
China
SynRx Therapeutics Co., Ltd.
31 Jul 2025
Ovarian CancerPhase 1
China
SynRx Therapeutics Co., Ltd.
31 Jul 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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