Delving into the Latest Updates on Nibentan with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

Potassium channel

Mechanism

Potassium channel blockers

Therapeutic Areas

Cardiovascular Diseases

Active Indication-

Inactive Indication

Arrhythmias, Cardiac

Originator Organization

Russian Academy of Medical Sciences

Active Organization-

Inactive Organization

Russian Academy of Medical Sciences

Drug Highest PhasePendingPhase 2

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaC22H30ClN3O3

InChIKeyCHCBAYRWJULIDW-UHFFFAOYSA-N

CAS Registry157832-56-9

A review.Publications on the design, synthesis, pharmacol. research, and clin. trials of the Russian original class III antiarrhythmic drugs nibentan {(RS)-4-nitro-N-[1-phenyl-5-(diethylamino)pentyl]benzamide hydrochloride} and niferidyl {4-nitro-N-[(1RS)-1-(4-fluorophenyl)-2-(1-ethylpiperidin-4-yl)ethyl]benzamide hydrochloride}are reviewed.

01 Dec 2011·PHARMACEUTICAL CHEMISTRY JOURNAL

Experience in creating new drugs using traditional technologies

Author: S. D. Yuzhakov ; R. G. Glushkov

A review. Working hypotheses for the creation of new potential drugs including Class III antiarrhythmic (nibentan, niferidyl), antiallergic (theoritin), and antituberculosis (hixozid) agents are formulated and exptl. data on the activity of the obtained compounds are presented.

01 Nov 2010·PHARMACEUTICAL CHEMISTRY JOURNAL

Metabolism and pharmacokinetics of nibentan in human blood plasma

Author: G. M. Rodchenkov ; V. A. Gorshkov ; A. B. Bezprozvannyi ; E. M. Zeltyn ; M. A. Dikunets ; A. V. Kukharenko ; A. E. Radzevich ; V. G. Valiev ; S. A. Appolonova

An HPLC method with electrospray ionization and ion-trap mass spectral detection (LC-ESI/MSD Ion Trap SL) for determining nibentan metabolites in human blood plasma is described.The proposed method provides simultaneous determination of nibentan and its metabolites in blood plasma.Three metabolites, hydroxylated, de-ethylated, and de-ethylated-hydroxylated, were found in human blood plasma after a single i.v. administration of nibentan (0.125 mg/kg, 1%).De-ethylated nibentan was the longest lived metabolite.The last 2 metabolites were found in human blood plasma for the first time.The results were verified and all metabolites were identified using LC-MS and LC-MS/MS.The major pharmacokinetic parameters were calculated

100 Deals associated with Nibentan

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