Last update 21 Nov 2024

Clobenzorex Hydrochloride

Last update 21 Nov 2024

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

Asenlix, Itravil Ap

+ [2]

Target-

Mechanism

Central nervous system stimulants

Therapeutic Areas

Endocrinology and Metabolic Disease

Active Indication

Obesity

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure

Molecular FormulaC16H18ClN

InChIKeyLRXXRIXDSAEIOR-ZDUSSCGKSA-N

CAS Registry13364-32-4

View All Structures (2)

100 Clinical Results associated with Clobenzorex Hydrochloride

100 Translational Medicine associated with Clobenzorex Hydrochloride

100 Patents (Medical) associated with Clobenzorex Hydrochloride

Literatures (Medical) associated with Clobenzorex Hydrochloride

01 Jul 2024·Journal of Forensic Sciences

Qualitative transformations of street‐seized ecstasy over a decade: A case study in Rio de Janeiro (Brazil)

Article

Author: Vanini, Gabriela ; de Oliveira, Marco Antônio Martins ; de Aquino Neto, Francisco Radler ; Cohen, Luciana Silva do Amaral ; Antonio, Ananda da Silva ; Bhering, Cecília de Andrade ; Wurzler, Gleicielle Tozzi ; de Oliveira, Adriana Sousa

AbstractThe illegal drug market is constantly evolving, with new drugs being created and existing ones being modified. Adulterants are often added to the mix, and the primary substance may be secretly replaced by a new one. Once‐known tablets can now be vastly different from what they are sold as, all due to the pursuit of profit and evasion of current drug regulations. These alterations in drug composition pose a threat to society, as their effects are still not well understood. Therefore, it is crucial for police intelligence and public health development to obtain the chemical profiles of illicit drugs. This study presents the chemical fingerprinting of ecstasy tablets seized in the state of Rio de Janeiro (Brazil) between 2012 and 2021. The tablet samples were weighed, extracted, diluted with methanol, and acidified before analysis using gas chromatography high‐resolution mass spectrometry and attenuated total reflection Fourier transform infrared spectroscopy. The major constituents found were MDMA and clobenzorex, with fewer occurrences of MDA, MDEA, and 2C‐B. The results also indicate that the occurrence of mega‐events in the study location impacted the chemical fingerprints of ecstasy. A total of 27 combinations of cutting agents, including caffeine, ephedrine, and anesthetics, were identified. Samples composed of clobenzorex were observed throughout the evaluated period in areas near highways, suggesting that this product is mainly used by truck drivers. These findings can help police intelligence units anticipate the behavior of the illicit market during major events, identify traffic routes, and support public health initiatives.

01 Jul 2024·Journal of Forensic Sciences

What's in drugs freely used by Brazilian truck drivers – “Rebites”? Determination of target and nontarget compounds by high‐resolution mass spectrometry and nuclear magnetic resonance

Article

Author: Barbieri, Rodrigo A ; Aguzzoli, Cesar ; Guizolfi, Tainara ; Kramer, Airton ; Moura, Sidnei ; Zardo, Giovana ; de Almeida, Rafael Menck

AbstractHighways, the lifeline of the Brazilian economy, transport approximately 75% of the country's economic activity, highlighting its importance. However, professional drivers, accustomed to long daily journeys, make use of tablets widely available in Gas Station, which are known as “Rebites,” which could contain a mixture of legal and illegal compounds. Thus, this study aims at the chemical characterization of these through different analytical methods. Initially, we performed a comprehensive screening of compounds present in seven samples collected across the country using high‐resolution mass spectrometry (HRMS). The findings revealed caffeine as the main compound, alongside theophylline, lidocaine, and clobenzorex, among others. In the next step, we employ quantitative nuclear magnetic resonance (qNMR) to quantify the caffeine content in the tablets. The results indicated a caffeine concentration ranging between 14% and 31% (m/m), which may imply a daily overdose of this compound from around four tablets. In summary, this investigation provides a chemical characterization of real samples of “Rebites” freely obtained along Brazilian highways. Caffeine emerged as the predominant active compound, with its concentration determined by qNMR analysis. The notable presence of caffeine, combined with other stimulants, depressants, and hallucinogens, underscores the need for strict quality control measures regarding “Rebites” to safeguard public health.

01 Jun 2024·Molecular Diversity

Exploration of interaction interface of TRKβ/BDNF through fingerprint analysis to disinter potential agonists

Article

Author: Satish, Kshreeraja S ; Hemasree, G N S ; Burri, Raghunadha R ; Murthy, T P Krishna ; Rajalekshmi, Saraswathy Ganesan

Tyrosine Kinase beta (TRKβ), is a type I membrane receptor which plays a major role in various signalling pathways. TRKβ was found to be upregulated in various cancers and contrastingly downregulated in various neurodegenerative disorders. Hitherto, contemporary drug research is oriented towards discovery of TRKβ inhibitors, thus neglecting the development of TRKβ agonists. This research is aimed at identifying FDA approved drugs exhibiting repurposable potential as TRKβ agonists by mapping them with fingerprints of the BDNF/TRKβ interaction interface. Initially, crucial interacting residues were retrieved and a receptor grid was generated around it. TRKβ agonists were retrieved from literature search and a drug library was created for each agonist based on its structural and side effect similarities. Subsequently, molecular docking and dynamics were performed for each library to identify the drugs possessing affinity towards the binding pocket of TRKβ. The study revealed molecular interactions of Perospirone, Droperidol, Urapidil, and Clobenzorex with the crucial amino acids lining the active binding pocket of TRKβ. Subsequent network pharmacological analysis of the above drugs revealed their interactions with key proteins involved in neurotransmitter signalling pathways. Clobenzorex displayed high stability in dynamics simulation and therefore this drug is recommended for further experimental evaluations to attain better mechanistic insights and predict its implications in correcting neuropathological aberrations. This study's focus on the interaction interface between TRKβ and BDNF, combined with the utilization of fingerprint analysis for drug repurposing, contributes to our understanding of neurotrophic signalling and holds potential for identifying new therapeutic options for neurological disorders.

100 Deals associated with Clobenzorex Hydrochloride

External Link

KEGG	Wiki	ATC	Drug Bank
-	Clobenzorex Hydrochloride	A08AA08	DB13561

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Obesity	-	-	-

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