Delving into the Latest Updates on BNP transdermal patch with Synapse

Overview

Basic Info

Drug Type

Synthetic peptide

Synonyms-

Target-

Mechanism-

Therapeutic Areas

Cardiovascular Diseases

Active Indication-

Inactive Indication

Heart Diseases

Originator Organization

Zosano Pharma Corp.

Active Organization-

Inactive Organization

Zosano Pharma Corp.

Drug Highest PhasePendingPhase 1

First Approval Date-

Regulation-

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Left ventricular obstruction is an invalidating complication of hypertrophic cardiomyopathies (HCM), and endothelial dysfunction has also been observed in these pathologies. However, the relation between obstruction and endothelial and venous dysfunctions has not been previously studied.
The main objective is to investigate the relations between endothelial and venous dysfunctions and symptomatic left ventricular outflow-tract obstruction in HCM patients.

Start Date22 Oct 2019

Sponsor / Collaborator

Amicus Therapeutics, Inc.

NCT03738878 / Active, not recruitingPhase 4IIT

Mechanism(s) Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 1

The purpose of this study is to test the hypothesis that combined angiotensin receptor blockade (ARB)/neprilysin (NEP) inhibition potentiates the effects of exogenous bradykinin, substance P, and brain natriuretic peptide (BNP) on forearm blood flow or endothelial tissue-type plasminogen activator (t-PA) release compared to ARB alone. A secondary goal is to determine if there is an interactive effect of ARB/NEP inhibition and dipeptidyl peptidase 4 (DPP4) inhibition on responses to these peptides.

Start Date15 Nov 2018

Sponsor / Collaborator

Vanderbilt University Medical Center

NCT01375153 / CompletedNot ApplicableIIT

Effects of Brain Natriuretic Peptide on Appetite-regulating Hormones and Endothelial-derived Peptides

Chronic heart failure is accompanied by anorexia and increased release of B-type natriuretic peptide (BNP) from the ventricular myocytes. The pathophysiological mechanisms linking heart failure and appetite-regulation remain unknown. This study aims to examine the impact of exogenous BNP administration on subjective ratings of hunger and satiety, and on appetite-regulating hormones in a placebo-controlled cross-over study performed in ten healthy human volunteers.

Start Date01 Nov 2010

Sponsor / Collaborator