NCC inhibitors(Thiazide-sensitive sodium-chloride cotransporter inhibitors), VAP-1 inhibitors(Amine oxidase, copper containing inhibitors), VMAT2 inhibitors(Synaptic vesicular amine transporter inhibitors)

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

Novartis Pharma AG

Active Organization-

Inactive Organization

Novartis Pharmaceuticals Corp.

Drug Highest PhaseWithdrawn

First Approval Date

US (11 Feb 1960)

Regulation-

Structure

Molecular FormulaC7H8ClN3O4S2

InChIKeyJZUFKLXOESDKRF-UHFFFAOYSA-N

CAS Registry58-93-5

View All Structures (3)

100 Clinical Results associated with Hydralazine hydrochloride/Hydrochlorothiazide/Reserpine

100 Translational Medicine associated with Hydralazine hydrochloride/Hydrochlorothiazide/Reserpine

100 Patents (Medical) associated with Hydralazine hydrochloride/Hydrochlorothiazide/Reserpine

Literatures (Medical) associated with Hydralazine hydrochloride/Hydrochlorothiazide/Reserpine

01 Jan 1988·Chemical and Pharmaceutical BulletinQ4 · MEDICINE

Blood pressure-lowering activity present in the fruit body of Grifola frondosa (Maitake). I.

Q4 · MEDICINE

Article

Author: Hisatora Kuroda ; Kyoko Adachi ; Hiroaki Nanba ; Masamichi Otsuka

A hypotensive substance was found in the maitake (Basidiomycetes) fruiting body.Spontaneously hypertensive rats (SHR) fed powd. fruiting bodies had lower blood pressure than control SHR in which the blood pressure increased with age.The dried Et₂O extract (ES) given orally (30 mg/kg) had a hypotensive effect but the H₂O extract was inactive.ES was dissolved in acetone, yielding an extract (ES-AS) and insoluble residue (ES-AP).Dried ES-AS and ES-AP given orally (30 mg/kg) reduced blood pressure by 45 and 65 mm Hg from the control value ≃220 mm Hg.After ES-AP separation into 5 fractions by thin layer chromatog., the most active fraction had R_f = 0.553.Combined treatment with maitake powder and 4 antihypertensive agents (hexamethonium, hydralazine, hydrochlorothiazide, reserpine) decreased blood pressure only in the combination with reserpine.This suggests that the blood pressure-lowering effect of maitake was brought about by a mechanism other than sympatholytic action.

01 Aug 1987·Journal of Cardiothoracic Anesthesia

Hypertensive crisis during coronary artery bypass graft surgery: A case of unsuspected pheochromocytoma

Article

Author: Carter, J G ; Hiratzka, L F ; Brom, D H ; Shimosato, S

I t has been reported that when the diagnosis of a pheochromocytoma is not made before anesthesia and surgery, hypertensive and/or hypotensive crisis may occur, possibly resulting in unexpected circulatgry shock or sudden death) '2 It is, therefore, essential to be alert for the possible existence of the disease, and to make a strong recommendation for routine preoperative screening for a pheochromocytoma in any recently diagnosed hypertensive patient. 3 However, many drugs, vitamins, and foodstuffs interfere with the analysis of urinary catecholamines an~t vanillylmandelic acid (VMA). 4 Thus, the Ser-Ap-Es (combination tablet of reserpine 0.1 mg, hydralazine hydrochloride 25 mg, and hydrochlorothiazide 15 mg). She also had type II diabetes mellitus, which was treated with 40 units of NPH insulin daily. Two months before entering the hospital for surgery, she was hospitalized following a prolonged episode of chest pain. However, no laboratory findings suggested an acute myocardial infarction. One month prior to the present admission, she was reevaluated for her symptoms, which consisted of chest pain, dyspnea on exertion, orthopnea, paroxysmal nocturnal dyspnea, and pedal edema. During a physical examination she experienced another episode of chest pain with ischemic changes on the electrocardiogram (ECG). Five days prior to the present admission, she was admitted to the Coronary Care Unit for follow-up. She was scheduled for cardiac catheterization since diagnosis of a pheochromocytoma is still considthere were no demonstrable changes in either serial ECGs or ered one of many challenging problems in clini! .'. efizyme studies. Her arterial blood pressure was usually in cal medicine) Hypertension is the clinical hall, . t he range of 130/70 mmHg, except for a few mild hypertenmark of a pheochromocytoma, but it is no t sive episodes (>160/80 mmHg), which were not related to always present. Headache, palpitations, and diaphoresis are common manifestations, but in rare cases the tumor may cause neither signs nor clinical symptoms. 6 The following case report illustrates the grave complications of an undiagnosed pheochromocytoma in a woman who was essentially asymptomatie until she underwent coronary artery bypass graft (CABG) surgery. She died of acute heart failure resulting from "malignant" hypertension and tachycardia during the perioperative period.

01 Sep 1972·Current therapeutic research, clinical and experimental

Reserpine, hydralazine, hydrochlorothiazide combination (Ser-AP-ES) in essential hypertension.

Article

Author: Glazer, N

100 Deals associated with Hydralazine hydrochloride/Hydrochlorothiazide/Reserpine

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Hydralazine hydrochloride/Hydrochlorothiazide/Reserpine

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