Delving into the Latest Updates on ASP-1948 with Synapse

Overview

Basic Info

Drug Type

Monoclonal antibody

Synonyms

Target

NRP-1

Action

inhibitors

Mechanism

NRP-1 inhibitors(Neuropilin-1 inhibitors)

Therapeutic Areas

Neoplasms

Active Indication

Locally Advanced Malignant Solid Neoplasm

Inactive Indication-

Originator Organization

Astellas Pharma, Inc.

Active Organization

Astellas Pharma Global Development, Inc.

Inactive Organization-

Drug Highest PhasePhase 1

First Approval Date-

Regulation-

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The purpose of this study is to evaluate the tolerability and safety profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab in participants with locally advanced (unresectable) or metastatic solid tumors; characterize the pharmacokinetic profile of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab and determine the recommended Phase 2 dose (RP2D) of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab. This study will also evaluate the antitumor effect of ASP1948 when administered as a single agent and in combination with nivolumab or pembrolizumab.

Start Date02 Jul 2018

Sponsor / Collaborator

Astellas Pharma Global Development, Inc.

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100 Clinical Results associated with ASP-1948

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100 Translational Medicine associated with ASP-1948

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100 Patents (Medical) associated with ASP-1948

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100 Deals associated with ASP-1948

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Locally Advanced Malignant Solid Neoplasm	Phase 1	South Korea	Astellas Pharma Global Development, Inc.	02 Jul 2018
Locally Advanced Malignant Solid Neoplasm	Phase 1	United Kingdom	Astellas Pharma Global Development, Inc.	02 Jul 2018
Locally Advanced Malignant Solid Neoplasm	Phase 1	Taiwan Province	Astellas Pharma Global Development, Inc.	02 Jul 2018
Locally Advanced Malignant Solid Neoplasm	Phase 1	Italy	Astellas Pharma Global Development, Inc.	02 Jul 2018
Locally Advanced Malignant Solid Neoplasm	Phase 1	Canada	Astellas Pharma Global Development, Inc.	02 Jul 2018
Locally Advanced Malignant Solid Neoplasm	Phase 1	United States	Astellas Pharma Global Development, Inc.	02 Jul 2018
Locally Advanced Malignant Solid Neoplasm	Phase 1	Portugal	Astellas Pharma Global Development, Inc.	02 Jul 2018
Locally Advanced Malignant Solid Neoplasm	Phase 1	Japan	Astellas Pharma Global Development, Inc.	02 Jul 2018
Locally Advanced Malignant Solid Neoplasm	Phase 1	Spain	Astellas Pharma Global Development, Inc.	02 Jul 2018

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Clinical Result

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Approval

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Biosimilar

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