AbstractWe report the case of a pregnant woman who suffered from hypotension after first exposure to intravenous administration of a combination drug containing vitamins B1, B6 and B12 (Vitamedin; Daiichi‐Sankyo, Tokyo, Japan). A 27‐year‐old Japanese woman received an intravenous infusion of fluid containing a vitamin B complex due to hyperemesis gravidarum. Thirty minutes after the start of infusion she was found to be in hypotension. The patient had stupor, general sweating, blood pressure of 82/50 mmHg, and low percutaneous oxygen saturation (SpO2) of 88%. We immediately stopped the infusion, lifted her legs and administered oxygen. Three minutes after these treatments, she quickly recovered to a good general condition. A skin prick test for vitamin B12 was positive, but tests for B1, B6, mannitol and saline were negative, indicating this adverse reaction was one of drug hypersensitivity due to the vitamin B12 in Vitamedin. Patients should be observed carefully immediately after the administration of Vitamedin.

01 Aug 1988·The Japanese journal of experimental medicine

Effect of vitamin B complex on the immunodeficiency produced by surgery of gastric cancer patients.

Article

Author: Takeshita, M ; Miyamoto, Y ; Akuzawa, Y ; Kishi, S ; Kurashige, S ; Fujii, N

We studied the effect of vitamin B complex (vitamin B1, B6 and B12 complex) on the immune responsiveness in gastric cancer patients who underwent surgery. The depression of blastogenic responses to both PHA and PWM was observed 2 weeks after surgery in half of the patients treated with Vitamedin but the degree was significantly less than that in the control patients without vitamin B treatment whose lymphocyte responses were depressed. Moreover, the blastogenic responses were induced by vitamin B administration 2 or 4 weeks after surgery in 5 of the 8 stage III-IV patients whose lymphocytes had not responded prior to surgery. Four weeks after surgery, the patients without vitamin B treatment showed only a tendency of recovery of their lymphocyte responses, whereas the recovery of blastogenic responses in the patients treated with vitamin B was significant. Essentially similar results were obtained with skin reactions to PHA and PPD. These results suggest that the administration of vitamin B1, B6 and B12 complex is useful for the protection against and the recovery of immune dysfunction produced by surgery in cancer patients.

01 Nov 1966·Shika gakuho. Dental science reports

[Clinical use of Vitamedin in oral surgery].

Article

Author: Katakura, S ; Koukita, Y ; Minaba, T

100 Deals associated with Benfotiamine/Pyridoxine hydrochloride/cyanocobalamin

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Indication	Country/Location	Organization	Date
Avitaminosis	Japan	Towa Pharmaceutical Co., Ltd.	01 Sep 2009
Avitaminosis	Japan	Alfresa Pharma Corp.	01 Sep 2009

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