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Last update 20 Mar 2025

Metronidazole Disodium Phosphate

Last update 20 Mar 2025

Overview

R&D Status

Clinical Result

Translational Medicine

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target-

Action

inhibitors

Mechanism

DNA synthesis inhibitors

Therapeutic Areas

Infectious Diseases

Active Indication

Anaerobic bacterial infection

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

Structure/Sequence

Molecular FormulaC6H10N3Na2O6P

InChIKeyYMFINCNGVIPIIM-UHFFFAOYSA-N

CAS Registry111682-58-7

100 Clinical Results associated with Metronidazole Disodium Phosphate

100 Translational Medicine associated with Metronidazole Disodium Phosphate

100 Patents (Medical) associated with Metronidazole Disodium Phosphate

Literatures (Medical) associated with Metronidazole Disodium Phosphate

01 Oct 1997·The American Journal of SurgeryQ3 · MEDICINE

Preventing infection of the incision after appendectomy by using metronidazole preoperatively to infiltrate tissues at the incision

Q3 · MEDICINE

Article

Author: Wang Shubing ; Zhang Litian

METHODSFrom January 1991 to July 1995, 260 patients with acute appendicitis were operated on. After excluding 21 patients, the remaining 239 cases were randomly divided into two groups. Group A was given the treatment and group B was the control group. Precisely 0.915 g metronidazole disodium phosphate injection (Tongzhen Pharmaceutical Co., Shan Xi Province, P. R. China) or 25% metronidazole glucose solution was added to 100 mL 0.9% normal saline. After anesthetizing the patients in group A, 60 to 80 mL of the solution was injected into the subcutaneous tissue and muscle. The control group B was given intravenous injection of metronidazole disodium phosphate and cephazolin postoperatively.RESULTSIn the 119 cases in group A, the rate of incision infection was 0.8%. By contrast, the rate of infection among the 120 cases in group B was 11.6%. The statistical analysis (chi square) was significant, with P < 0.001 showing that preincisional or intraincisional infiltration with metronidazole was effective.

01 Sep 1992·Drug Metabolism and Drug Interactions

A Comparison of Metronidazole Distribution Following Intravenous Metronidazole and Metronidazole Phosphate Disodium in Mice

Article

Author: Qu, Shouwei ; Li, Tun

The distribution of metronidazole following intravenous metronidazole (MTZ) and metronidazole phosphate disodium (MNP) in mice was investigated by HPLC. The results showed no significant differences in the metronidazole concentrations of liver, kidney, heart, spleen, fat, brain, lung, stomach, jejunum, skeletal muscle, ovary, testis and epididymis (P greater than 0.05). It can be concluded that using MNP as a water-soluble substitute for MTZ should not influence the distribution of metronidazole in mice.

Zhongguo Yiyao Gongye Zazhi

Synthesis of metronidazole disodium phosphate

Author: Li, Qingeng ; Xu, Qigui ; Tian, Rui

Metronidazole disodium phosphate monohydrate was synthesized from metronidazole by esterification with POCl₃ and hydrolysis to give metronidazole monophosphate, and then formed sodium salt in 85% overall yield.

100 Deals associated with Metronidazole Disodium Phosphate

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Anaerobic bacterial infection	China	-	-

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Metronidazole Disodium Phosphate

Overview

Basic Info

Structure/Sequence

Related

R&D Status

Clinical Result

Translational Medicine

Deal

Core Patent

Clinical Trial

Approval

Regulation