4-hydroxybenzaldehyde (Yunnan University of Chinese Medicine)

The limited toughness of epoxy resins (EP) significantly hinders their application.While hyperbranched polymers are commonly employed as toughening agents, their poor solubility often leads to drawbacks, including a marked reduction in glass transition temperature (T_g).In this study, a novel hyperbranched poly(aryl ether ketone) resin (pm-HBPAEK-OH) with enhanced solubility was synthesized and evaluated as a toughening agent, for EP.The results indicated that when the content of pm-HBPAEK-OH is 6%, the tensile strength, flexural strength, impact strength, and elongation at break reached 75.1 MPa, 113.8 MPa, 43.5 kJ/m², and 11.3%, resp., representing enhancements of 10.0%, 13.1%, 112.9%, and 195.0% compared to the pure EP.Addnl., the modified EP exhibited superior thermal stability achieving a T_g of 91.6°C, which is approx. 15.4°C higher than that of pure EP, without a significant loss in thermal decomposition temperature

The ever-increasing drug-resistant tuberculosis (TB) has invigorated the focus on the discovery and development of novel therapeutic agents and treatment options. Thiazolidinone-based compounds have shown good antitubercular properties in vitro. Here, we report the design and synthesis of a number of new derivatives inspired by the structure of thiazolidine-2,4-dione (TZD). The TZD-based hybrids with the thiosemicarbazone or the pyridinecarbohydrazone moiety were synthesised and their antimycobacterial activity was investigated against the reference H₃₇Rv and two wild Mycobacterium tuberculosis (Mtb) strains. In further studies, a two-drug interaction analysis was also performed for assessing their synergism with the current first-line drugs used for the treatment of TB. It was found that some of the compounds showed high antimycobacterial activity with MICs (0.078-0.283 µM) and a synergistic effect with isoniazid or rifampicin, thereby demonstrating their potential as a promising scaffold for the development of novel coadjuvants for the effective treatment of TB.