Article
Author: Penning, T. M. ; Cancellieri, M. A. ; Schultz, T. W. ; Botelho, D. ; Tokura, Y. ; Burton, G. A. Jr. ; Belsito, D. ; Dekant, W. ; Thakkar, Y. ; Moustakas, H. ; Jones, L. ; Na, M. ; Siddiqi, F. ; Deodhar, C. ; Joshi, K. ; Chon, H. ; Selechnik, D. ; Muldoon, J. ; Sipes, I. G. ; Kumar, M. ; Ritacco, G. ; Api, A. M. ; Fryer, A. D. ; Sadekar, N. ; Sullivan, G. ; Bruze, M. ; Romine, J. ; Liebler, D. C. ; Lavelle, M. ; Dagli, M. L. ; Lapczynski, A. ; Lee, I.
A review.4-Hydroxybenzaldehyde was evaluated for genotoxicity, repeated dose toxicity, reproductive toxicity, local respiratory toxicity, photoirritation/photoallergenicity, skin sensitization, and environmental safety.Target data and data from read-across analog salicylaldehyde (CAS # 90-02-8) show that 4-hydroxybenzaldehyde is not expected to be genotoxic.Data on read-across analog salicylaldehyde (CAS # 90-02-8) provide a calculated Margin of Exposure (MOE) > 100 for the repeated dose toxicity and reproductive toxicity endpoints.Data show that there are no safety concerns for 4-hydroxybenzaldehyde for skin sensitization under the current declared levels of use.The photoirritation endpoint was evaluated based on data; 4-hydroxybenzaldehyde is not a concern for photoirritation.4-Hydroxybenzaldehyde has not been fully evaluated for photoallergenicity.The local respiratory toxicity endpoint was evaluated using the Threshold of Toxicol. Concern (TTC) for a Cramer Class I material, and the exposure to 4-hydroxybenzaldehyde is below the TTC (1.4 mg/day).The environmental endpoints were evaluated; 4-hydroxybenzaldehyde was found not to be Persistent, Bioaccumulative, and Toxic (PBT) as per the International Fragrance Association (IFRA) Environmental Standards,.