Last update 11 Oct 2025

Acolbifene Hydrochloride/Prasterone

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Acolbifene/prasterone, Dehydroepiandrosterone/Acolbifene, DHEA/Acolbifene
+ [2]
Target
AR x ER
Action
agonists
Mechanism
AR agonists(Androgen Receptor agonists), ERs agonists(Estrogen receptors agonists)
Therapeutic Areas
Cardiovascular DiseasesEndocrinology and Metabolic DiseaseOther Diseases+ [2]
Active Indication-
Inactive Indication
Breast CancerDecreased libidoHot Flashes+ [2]
Originator Organization
Endoceutics, Inc.Endoceutics, Inc.
Active Organization-
Inactive Organization
Endoceutics, Inc.Endoceutics, Inc.
License Organization-
Drug Highest PhaseDiscontinuedPhase 3
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC29H31NO4
InChIKeyDUYNJNWVGIWJRI-LJAQVGFWSA-N
CAS Registry182167-02-8
View All Structures (2)

Related

1
Clinical Trials associated with Acolbifene Hydrochloride/Prasterone
NCT01452373
/ CompletedPhase 3
DHEA + Acolbifene Against Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women (Placebo Controlled, Double Blind and Randomized Phase III Study to Evaluate the Effects of 12-Week Treatment With DHEA (Prasterone) and Acolbifene on Vasomotor Symptoms (Hot Flushes) in Postmenopausal Women)
100 Clinical Results associated with Acolbifene Hydrochloride/Prasterone
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100 Translational Medicine associated with Acolbifene Hydrochloride/Prasterone
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100 Patents (Medical) associated with Acolbifene Hydrochloride/Prasterone
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100 Deals associated with Acolbifene Hydrochloride/Prasterone
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Hot FlashesPhase 3
Canada
Endoceutics, Inc.Endoceutics, Inc.
01 Oct 2011
Vascular DiseasesPhase 3
Canada
Endoceutics, Inc.Endoceutics, Inc.
01 Oct 2011
Decreased libidoPhase 3
Canada
Endoceutics, Inc.Endoceutics, Inc.
-
HypogonadismPhase 3
Canada
Endoceutics, Inc.Endoceutics, Inc.
-
Breast CancerPreclinical
Canada
Endoceutics, Inc.Endoceutics, Inc.
-
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

No Data

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Clinical Trial

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Approval

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Regulation

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