Author: Droitcourt, Catherine ; Delaunay, Juliette ; Osmont, Marie Noelle ; Avenel‐Audran, Martine ; Dupuy, Alain ; Cariou, Claire ; Adamski, Henri ; Marguery, Marie Claude ; Dutartre, Hervé

AbstractBackgroundIn Europe, contact photosensitivity to phenothiazines is well‐known, particularly in southern countries. Topical phenothiazines are widely used and sold over‐the‐counter (OTC) for the treatment of mosquito bites and pruritus in France.ObjectiveTo report a series of cases with photodermatitis following use of topical phenothiazines.MethodA retrospective study of cases of contact dermatitis from phenothiazines seen in French photodermatology centers was performed.ResultsIn all, 14 patients with a diagnosis of contact dermatitis from phenothiazines were included. These patients developed eczema on the application sites, and in 13 the eruption spread to photodistributed sites. Topical products containing isothipendyl were the most common cause of photodermatitis. One patient had photoaggravated eczema due to promethazine cream. All patients stopped using topical phenothiazines and were treated successfully with topical corticosteroids. One patient relapsed and developed persistent light eruption. In all of the nine cases tested, photopatch testing to the topical phenothiazine used “as is” was positive. Isothipendyl, chlorproethazine, and the excipients were not tested. Photopatch tests to chlorpromazine and promethazine were positive in 8 of 12 and 7 of 13 tested, respectively.ConclusionUse of isothipendyl and promethazine as OTC (or even prescribed) drugs needs to be limited due to severe reactions and sensitization to other phenothiazines that consequently will have to be avoided.

01 Mar 2003·Analytical SciencesQ4 · CHEMISTRY

Extractive Spectrophotometric Determination of Fluoroquinolones and Antiallergic Drugs in Pure and Pharmaceutical Formulations

Q4 · CHEMISTRY

Article

Author: Babu G. Gowda ; Jaldappa Seetharamappa

A simple, rapid and sensitive spectrophotometric procedure has been proposed for the assay of fluoroquinolones viz., ciprofloxacin (CPF) and norfloxacin (NRF), and antiallergic drugs viz., methdilazine hydrochloride (MDH) and isothipendyl hydrochloride (IPH) in bulk and pharmaceutical formulations. The method is based on the reaction of selected drugs with Brilliant Blue G (BBG) in NaOAc-AcOH buffer of pH 4.0 for CPF and NRF or in neutral medium for MDH and IPH to give chloroform soluble ion-association complexes. The effects of various parameters have been studied. The ion-association complexes exhibited absorption maxima at 610 nm for CPF, at 614 nm for NRF and MDH, and at 612 nm for IPH. Beer's law plots were obeyed in the concentration ranges of 0.5-6.0, 0.4-8.0, 0.1-6.0 and 0.2-6.1 (mg ml(-1) for CPF, NRF, MDH and IPH, respectively, with correlation coefficients not less than 0.9969. Molar absorptivity values as calculated from the Beer's law data were found to be 2.86 x 10(4), 2.64 x 10(4), 3.13 x 10(4) and 5.51 x 10(4) mol(-1) cm(-1) for CPF, NRF, MDH and IPH, respectively. The influence of commonly employed excipients in the determination of the studied drugs has been studied. The results obtained by the proposed method were statistically validated.

01 Jan 2003·Indian journal of environmental health

Spectrophotometric studies on the investigation of chromium in environmental samples.

Article

Author: Seetharamappa, Jaldappa ; Melwanki, M B

Isothipendyl hydrochloride is proposed as a sensitive and selective reagent for the rapid spectrophotometric determination of chromium(VI). The reagent instantaneously gives a red coloured species on reaction with chromium(VI) in phosphoric acid medium which exhibits maximum absorbance at 510 nm with Sandell's sensitivity of 2.28 ng cm(-2). Beer's law is valid over the concentraction range of 0.1-1.9 mg/l with an optimum concentration range of 0.2-1.7 mg/l. The method has been successfully applied to the analysis of chromium in environmental samples.

100 Deals associated with Isothipendyl Hydrochloride

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KEGG	Wiki	ATC	Drug Bank
D01143	Isothipendyl Hydrochloride	R06AD09 D04AA22	DB08802

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