Author: Moreno-Chamba, Bryan ; Valero, Manuel ; Berna, Genoveva ; Salazar-Bermeo, Julio ; Martinez-Madrid, Maria Concepcion ; Neacsu, Madalina ; Saura, Domingo ; Martin-Bermudo, Francisco ; Marti, Nuria ; Lizama, Victoria

Persimmon byproduct upcycling was performed by solvent-assisted extraction (SAE) to obtain dietary fiber (DF).The effect of SAE on DF modulation was studied on specific beneficial and pathogenic strains before and after the in vitro digestion process.Overall, digested DF samples extracted using acetone as a solvent (dCET) showed higher (p < 0.05) prebiotic activity scores (PASs) in beneficial bacteria such as Bifidobacterium bifidum, Lactobacillus casei, Lactococcus lactis, and Streptococcus salivarius.Moreover, dCET reduced the tested pathogenic strain populations.Initial cell attachment (ICA) inhibitory activity on biofilm formation by Pseudomonas putida, Staphylococcus aureus and Bacillus subitilis was observed for dCET, as well as inhibition of preformed (PFB) S. aureus biofilms. dCET combined with the antibiotics kanamycin (K) or gentamycin (G) exhibited synergistic effects against all tested pathogens, displaying bactericidal effects against S. aureus.High-performance liquid chromatog. (HPLC-DAD) anal. showed that after hydrolysis, the released gallic acid could have been responsible for the antimicrobial properties registered in DF from the persimmon byproduct.The obtained results provided information about the potential of upcycled persimmon fiber fractions as possible prebiotics, although further research must be performed with complex microbial populations and in vivo studies.

01 Jun 2010·European Journal of PharmacologyQ3 · MEDICINE

Anti-fatigue effect of dicethiamine hydrochloride is likely associated with excellent absorbability and high transformability in tissues as a vitamin B1

Q3 · MEDICINE

Article

Author: Nozaki, Satoshi ; Watanabe, Yasuyoshi ; Nishi, Shugo ; Shimizu, Toshikatsu ; Hoshino, Hiroshi

The anti-fatigue effect of dicethiamine hydrochloride (DCET) was assessed and compared to that of thiamine hydrochloride (VB(1)HCl) in rats. The absorbability and tissue distribution of thiamine after oral administration of DCET and VB(1)HCl were also examined. To create fatigued animals, male SD rats were placed in plastic cages containing 1.5cm of water for 5 consecutive days. The extent of fatigue was evaluated by a weight-loaded forced swimming test. After oral administration of DCET or VB(1)HCl to non-fatigued rats, blood and tissues were serially collected to determine the concentrations of thiamine and its phosphate esters. Pharmacokinetic analysis was performed to examine the thiamine profile in the body after administration of DCET or VB(1)HCl. Swimming time was significantly shorter for the fatigued vehicle group than the non-fatigued group. DCET (30 and 100mg/kg) significantly prolonged the swimming time compared to the fatigued vehicle group. The anti-fatigue effect of VB(1)HCl (70.1mg/kg) was not significant in our set of results. Both DCET and VB(1)HCl were rapidly absorbed into the circulating blood as thiamine and eventually became localized in the organs. Thiamine was distributed at higher concentrations to the blood, heart, thigh muscles, cerebellum, hippocampus, and thalamus after administration of DCET compared to VB(1)HCl. These results indicate that DCET is a vitamin B(1) derivative that has excellent absorbability and transformability in tissues and suggest that DCET as an oral therapy may be useful against combined mental and physical fatigue, such as that often encountered in contemporary society.

01 Jan 1979·YAKUGAKU ZASSHIQ4 · MEDICINE

A Study on the Weight Variation Test of Tablets

Q4 · MEDICINE

Article

Author: Johno, Ikuo ; Kitazawa, Shikifumi ; Mizugaki, Ichiro ; Maeda, Atsushi ; Obata, Hideo

Fifty-four brands of com., uncoated and coated tablets were selected at random and subjected to the weight variation test of the Japanese Pharmacopeia (J.P.IX).For comparison purposes, four formulated uncoated tablets, were included in this study.All uncoated tablets complied with the requirements of the J.P.IX.Variations in tablet weight, presented as standard deviation and/or range, increased with the average weight increase of the tablets.However, the variations were considerably less than the requirements.This suggests that the requirements should be updated since they do not adapt to present status of table formulations.More than 80% of the coated tablets complied with the requirements which are applied only to uncoated tablets in the J.P.IX.It was apparent that the variations in coated tablets were not as small as those of uncoated tablets; however, the fact that more than 80% of the coated tablets complied with the J.P. requirements suggests that some requirement should be established for the coated preparations

100 Deals associated with Cetotiamine Hydrochloride Hydrate

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KEGG	Wiki	ATC	Drug Bank
D03292	-	A11DA	-

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Indication	Country/Location	Organization	Date
Thiamine Deficiency	Japan	Takata Seiyaku Co., Ltd.	27 Jan 1965

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