Last update 15 Nov 2025

SB-247853

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
SB 247853
Target
5-HT2C receptor
Action
inverse agonists
Mechanism
5-HT2C receptor inverse agonists(Serotonin 2c (5-HT2c) receptor inverse agonists)
Therapeutic Areas
Nervous System Diseases
Active Indication-
Inactive Indication
Depressive Disorder, Major
Originator Organization
GSK PlcGSK Plc
Active Organization-
Inactive Organization
GSK PlcGSK Plc
License Organization-
Drug Highest PhaseDiscontinuedPhase 1
First Approval Date-
Regulation-
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Structure/Sequence

Molecular FormulaC22H19F3N4O2
InChIKeyKLAHZRONIHBPPB-UHFFFAOYSA-N
CAS Registry200711-10-0

Related

100 Clinical Results associated with SB-247853
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100 Translational Medicine associated with SB-247853
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100 Patents (Medical) associated with SB-247853
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2
Literatures (Medical) associated with SB-247853
01 Nov 2005Bioorganic & medicinal chemistry lettersQ4 · MEDICINE
A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists
Q4 · MEDICINE
01 Aug 2000Bioorganic & medicinal chemistry lettersQ4 · MEDICINE
1-[2-[(Heteroarylmethoxy)aryl]carbamoyl]indolines are selective and orally active 5-HT2C receptor inverse agonists
Q4 · MEDICINE
100 Deals associated with SB-247853
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Depressive Disorder, MajorPhase 1
United Kingdom
GSK PlcGSK Plc
-
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Clinical Result

Indication
Phase
Evaluation
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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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