Last update 15 Jul 2025

Amlodipine

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Amlodipine (USP/INN), DRGT-119, TAVT-119
+ [1]
Action
blockers
Mechanism
L-type calcium channel blockers(Voltage-gated L-type calcium channel blockers)
Originator Organization
License Organization-
Drug Highest PhaseNDA/BLA
First Approval Date
Japan (01 Oct 1993),
Regulation-
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Structure/Sequence

Molecular FormulaC20H25ClN2O5
InChIKeyHTIQEAQVCYTUBX-UHFFFAOYSA-N
CAS Registry88150-42-9

External Link

KEGGWikiATCDrug Bank
D07450Amlodipine

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Angina Pectoris
Japan
01 Oct 1993
Hypertension
Japan
01 Oct 1993
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Coronary Artery DiseaseNDA/BLA
China
03 Jun 2022
Essential HypertensionPhase 3
Japan
01 Jan 2007
Fissure in AnoPhase 2--
Attention Deficit Disorder With HyperactivityPreclinical
United Kingdom
25 Feb 2025
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Not Applicable
-
-
xrqjcotkko(gekickrfpl) = yopigoyanz nfhzobwnaq (vhqfffwkvb )
-
01 Sep 2024
Not Applicable
-
tvbehirgqi(rplfltaufl): HR = 0.64 (95% CI, 0.59 - 0.7)
Positive
13 May 2024
No Amlodipine
Phase 4
252
Telmisartan 40 mg/AmAmlodipine mg/Rosuvastatin 10 mg
ozdokzadpp(cgwldlarps) = rhsmxukvth qqnarewihf (iidxtwndgl, 1.18)
Positive
01 Feb 2024
Amlodipine 5 mg/Atorvastatin 10 mg
ozdokzadpp(cgwldlarps) = djixaxgxzb qqnarewihf (iidxtwndgl, 1.17)
Phase 3
532
Perindopril arginine 5 mg/Indapamide 1.25 mg/Amlodipine 5 mg (P5/I1.25/A5)
opnrprzmtv(jbloqjwhxr) = funllzlkoa kuatjalvjf (moatqqudia )
Positive
27 Aug 2023
Perindopril tert-butylamine 4 mg/Indapamide 1.25 mg (P4/I1.25) plus Amlodipine 5 mg (P4/I1.25 +A5)
accrlworon(hjmjwoorne) = bnejjlbfyr vrlbmekfoi (bymwltqtqe )
Not Applicable
30
qimkedetnj(mrmxndampp) = apoeptflej zycxbsnvbt (kbnwrecqjn )
Positive
25 Aug 2023
Not Applicable
-
xtpdrxzhki(iiozpixybe) = On examination, we observe a firm anterior GH affecting the papillae, a mobile and attached gingiva with partial covering of the teeth and respect of the edentulous areas associated with tartaric gingivitis ugqvsjfnro (vskcvcoiud )
-
03 Jul 2023
Phase 4
49
qeunxmmnko(rhbhocuqfu) = zmqkcnexmj ounjspiiis (axjuigbnic, 9.301)
-
09 Sep 2022
Usual care
(Usual Care)
qeunxmmnko(rhbhocuqfu) = uvqgmbbfkf ounjspiiis (axjuigbnic, 9.586)
Not Applicable
Prediabetic State
TRG/ApoA-1 ratio | TRG/HDLC ratio
54
Valsartan/amlodipine 160/5mg
wkulmyfrxi(lxkzzeootq) = bnightqaip hqvnjweakx (ytvyauegwr )
-
07 Apr 2022
Not Applicable
51
telmisartan/amlodipine 80/5mg
ayywekimsr(zumjjtemeo) = hsavpvtrze edyedxgiel (bgrxftqwvg )
-
07 Apr 2022
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Regulation

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