Delving into the Latest Updates on Aluminum Chloride Hexahydrate with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

aluminum chloride hexahydrate, Drysol

Target-

Action-

Mechanism-

Therapeutic Areas

Skin and Musculoskeletal Diseases

Active Indication

Hyperhidrosis

Inactive Indication-

Originator Organization-

Active Organization-

Inactive Organization-

Drug Highest PhaseApproved

First Approval Date-

Regulation-

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Structure/Sequence

Molecular FormulaAlCl3H12O6

InChIKeyJGDITNMASUZKPW-UHFFFAOYSA-K

CAS Registry7784-13-6

The objective is to establish an evidence base for a hyperhidrosis treatment algorithm in amputees. This project will address a problem that has troubled Service members, Veterans, and civilians with amputations for decades, impacting satisfaction with prosthetic use, residual limb skin health, and negatively affecting quality of life. Prior research in this area has been limited and insufficient. The Investigators are confident that improving the evaluation and treatment of residual limb hyperhidrosis will reduce the secondary health consequences of amputation and will lead to improved quality of life. This will be accomplish by completing the following specific aims.
Aim 1: Test the validity of the Minor iodine-starch test in amputees. Hypothesis: The iodine-starch test is a valid diagnostic tool of hyperhidrosis and can be useful for the identification of focal areas of sweating on a residual limb Aim 2: Test the effectiveness of a prescription strength topical antiperspirant (Aluminum Chloride 20%) on hyperhidrosis of the residual limb.
Hypothesis: Aluminum Chloride will be more effective at controlling sweating than placebo

Start Date08 May 2018

Sponsor / Collaborator

University of Utah

[+2]

IRCT20160506027762N2

/ CompletedPhase 3IIT

Comparative evaluation of iontophoresis with aluminum chloride hexahydrate gel versus iontophoresis with Tap water in people with primary palmar hyperhidrosis

Start Date21 Jan 2018

Sponsor / Collaborator

Shahid Beheshti University of Medical Sciences

100 Clinical Results associated with Aluminum Chloride Hexahydrate

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100 Translational Medicine associated with Aluminum Chloride Hexahydrate

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100 Patents (Medical) associated with Aluminum Chloride Hexahydrate

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1,451

Literatures (Medical) associated with Aluminum Chloride Hexahydrate

01 Mar 2025·Analytical Biochemistry

Esterase-2 mutant-based nanostructured amperometric biosensors for the selective determination of paraoxon (Neurotoxin)

Article

Author: Magar, Hend Samy ; Febbraio, Ferdinando ; Fayez, Muhammad ; Hassan, Rabeay Y A

Organophosphate pesticides (OPs) are causing non-selective inhibition in enzymatic bioreceptors, thus the enzymatic-inhibition-based traditional assays are not suitable for their specific detection in food and environmental samples. Accordingly, a selective nanostructured electrochemical biosensing system was designed using six mutants of the esterase-2 (EST2 protein) enzymes from A. acidocaldarius to be exploited as targeting bio-receptors for the specific detection of OPs. Each of the EST2 mutant enzymes was immobilized on disposable screen-printed electrodes modified with Aluminum oxide (Al₂O₃)/Copper (Cu) nanocomposite. Consequently, chronoamperometric assay was fully optimized, and cross-reactivity study was carried out using paraoxon, malathion and chlorpyrifos. The comparative cross-reactivity study was performed on the six mutant proteins in terms of inhibitory percentage over a wide range of pesticide concentrations. Eventually, a wide dynamic inhibition range was achieved while the limit of detection for the paraoxon toxicity was 0.01 nM and the limit of quantification was 0.05 nM. Finally, paraoxon was selectively determined using the newly developed EST-based biosensor in different spiked food samples.

01 Mar 2025·Journal of Non-Crystalline Solids

Flexible, transparent, flame-retardant cellulose/silica–aluminum composite aerogel films for thermal management

Author: Cui, Sheng ; Sun, Jing ; Hu, Ziyi ; Shen, Xiaodong ; Zhu, Xiaofei ; Wu, Qing ; Zhong, Ya ; Ding, Wen

As the global climate tends to become more extreme, high-performance thermal management materials are important for the comfort of human existence.Cellulose-based aerogels have become a hot research hotspot due to their abundant raw materials and good mech. properties.Herein, cellulose/silica-aluminum composite aerogels (CSAL) with organic-inorganic structures were obtained by in situ formation of silica-aluminum aerogel nanoparticles via a two-step sol-gel process, which was prepared by dissolving cotton pulp in the ionic liquidRelated properties are investigated with Fourier transform IR spectroscopy, SEM, UV-visible spectrometer, N₂ adsorption, compression tests, thermogravimetric anal., and ignition tests.The resulting CSAL samples have low d. (0.112-0.133 g/cm³), high sp. surface area (252.65-464.02 m²/g), good mech. properties, and excellent transmittance (>60 %).Thus, the as-prepared high-performance cellulose/silica-aluminum composite aerogel films with flexible, transparent, flame retardant, which have great potential for application in lightweight energy-efficient buildings, household equipment and other fields requiring thermal insulation.

01 Mar 2025·ChemPlusChem

Preparation and Catalytic Properties of Gold Single‐Atom and Cluster Catalysts Utilizing Nanoparticulate Mg‐Al Layered Double Hydroxides

Article

Author: Ishida, Tamao ; Honma, Tetsuo ; Nakayama, Akihiro ; Shimada, Tetsuya ; Sakaguchi, Norihito ; Murayama, Toru ; Takagi, Shinsuke ; Taketoshi, Ayako ; Yoshida, Ayano ; Aono, Chika ; Fujita, Takashi

AbstractAu single atoms and clusters were stabilized on Mg−Al layered double hydroxide nanoparticles (LDH NPs), and the obtained Au@LDH NPs were supported on SiO2 and CeO2. After hydrogen reduction, Au single atoms were found together with Au clusters on LDH/SiO2. In contrast to Au single‐atom catalysts which are deposited in metal vacancies of oxide supports, the LDH NPs stabilize very small Au species despite the absence of metal vacancies. The obtained Au(0)@LDH/SiO2 catalyzed aerobic oxidation of alcohols, and Au single atoms maintained after the reaction. Given that only Au NPs were observed on bulk LDH, the abundant surface OH group of LDH NPs would contribute to stabilize Au, resulting in higher activity than Au/LDH‐bulk. After calcination to transform LDH to mixed metal oxide (MMO), the obtained Au(0)@MMO/SiO2 also exhibited high catalytic activity. Moreover, Au(0)@LDH/CeO2 exhibited higher activity and excellent selectivity for hydrogenation of 4‐nitrostyrene to 4‐aminostyrene than conventional Au catalysts such as Au/CeO2 and Au/TiO2. We demonstrated that Au size can be minimized using LDH NPs, exhibiting high catalytic performance. The basic surface OH groups of LDH would be also beneficial for deprotonation of alcohols and heterolytic dissociation of H2 in the catalytic reactions.

100 Deals associated with Aluminum Chloride Hexahydrate

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