Last update 15 May 2025

HRS-2398

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
HRS 2398, HRS-2398, HRS2398
Target
ATR
Action
inhibitors
Mechanism
ATR inhibitors(Serine-protein kinase ATR inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Advanced Malignant Solid NeoplasmAdvanced cancer
Inactive Indication-
Originator Organization
Shanghai Hengrui Pharmaceutical Co., Ltd.Shanghai Hengrui Pharmaceutical Co., Ltd.
Active Organization
Shanghai Hengrui Pharmaceutical Co., Ltd.Shanghai Hengrui Pharmaceutical Co., Ltd.Jiangsu Hengrui Pharmaceuticals Co., Ltd.Jiangsu Hengrui Pharmaceuticals Co., Ltd.
Inactive Organization-
License Organization-
Drug Highest PhasePhase 1/2
First Approval Date-
Regulation-
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Related

3
Clinical Trials associated with HRS-2398
CTR20241965
/ RecruitingPhase 1/2
HRS2398联合阿得贝利单抗注射液治疗晚期实体肿瘤的开放、多中心Ⅰb/Ⅱ期临床研究
[Translation] An open, multicenter phase Ib/II clinical study of HRS2398 combined with adebelimumab injection in the treatment of advanced solid tumors
NCT06439589
/ RecruitingPhase 1/2
An Open-label, Multi-center Phase Ib/II Study of HRS2398 in Combination With Adebrelimab in Patients With Advanced Solid Tumors
NCT05144061
/ CompletedPhase 1
A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics (PK) of HRS2398 in Subjects With Advanced Malignant Tumors
100 Clinical Results associated with HRS-2398
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100 Translational Medicine associated with HRS-2398
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100 Patents (Medical) associated with HRS-2398
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100 Deals associated with HRS-2398
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Advanced Malignant Solid NeoplasmPhase 2
China
Shanghai Hengrui Pharmaceutical Co., Ltd.Shanghai Hengrui Pharmaceutical Co., Ltd.
12 Jun 2024
Advanced cancerPhase 1
China
Jiangsu Hengrui Pharmaceuticals Co., Ltd.Jiangsu Hengrui Pharmaceuticals Co., Ltd.
20 Dec 2021
Solid tumorPhase 1
China
Jiangsu Hengrui Pharmaceuticals Co., Ltd.Jiangsu Hengrui Pharmaceuticals Co., Ltd.
20 Nov 2021
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Clinical Result

Indication
Phase
Evaluation
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Core Patent

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Clinical Trial

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Approval

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Regulation

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