TAC-101 (Triumvira)

SAN DIEGO and AUSTIN, Texas and HAMILTON, ON, Oct. 30, 2024 /PRNewswire/ -- Triumvira Immunologics, a clinical-stage company developing novel, targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with solid tumors, today announced that Dr. Ecaterina E. Dumbrava, Assistant Professor in the Department of Investigational Cancer Therapeutics at The University of Texas MD Anderson Cancer Center, will present a late-breaking abstract at the 39th Annual Meeting of the Society for Immunotherapy of Cancer (SITC) 2024, being held from November 6-10, 2024, in Houston, Texas. The oral presentation will highlight interim data from Triumvira's ongoing Phase 1/2 study, TACTIC-3 clinical trial, which is investigating the safety and efficacy of TAC101-CLDN18.2, a novel T cell therapy targeting Claudin 18.2+ advanced solid tumors. The therapy leverages Triumvira's proprietary T cell Antigen Coupler (TAC) technology, a unique platform that activates natural T cell functions to combat solid tumors effectively and safely. "We are excited to share promising initial results from our TACTIC-3 trial at SITC 2024," said Robert Williamson, President of Triumvira Immunologics. "Our approach harnesses the body's natural immune system to target challenging cancers like Claudin 18.2+ solid tumors. This represents a significant advancement in our mission to develop next-generation cell therapies that could transform the treatment landscape for patients with difficult-to-treat cancers." Details of the abstract presentation are as follows: Abstract Number: 1472 Abstract Title: A phase 1/2 study evaluating the safety and efficacy of autologous TAC T cells in subjects with claudin 18.2+ advanced solid tumors Authors: Ecaterina E. Dumbrava, Syma Iqbal, Simon Turcotte, Gregory Botta, Benjamin Schlechter, Geoffrey Ku, Peter Hosein, Sam Saibil, Miriam Gavriliuc, Maria Apostolopoulou, Mobolaji Giwa, Kara Moss, Swaminathan Murugappan, Davendra Sohal Session: Biotech Breakthroughs – Solid Tumor IO at the Tipping Point Date: Friday, November 8, 2024, between 1:45 p.m. and 3:20 p.m. CDT About TACTIC-3 The TACTIC-3 trial (NCT05862324) is a first-in-human Phase 1/2 study designed to evaluate the safety, recommended Phase II dose (RP2D), pharmacokinetics, and efficacy of TAC101-CLDN18.2 in patients with Claudin 18.2+ solid tumors who have undergone 2 or more lines of prior therapy (1 prior line in patients with pancreatic tumors). The trial includes subjects with advanced gastric and other solid tumors expressing Claudin 18.2, with the potential to address significant unmet medical needs in oncology. About Triumvira Immunologics Triumvira Immunologics, Inc. ("Triumvira") is a leading clinical-stage solid tumor cell therapy company developing unique, non-gene edited, first-in-class targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with solid tumors. The company's proprietary T cell Antigen Coupler (TAC) technology platform activates natural T cell functions differently from other cell therapies such as CAR-T and engineered T cell receptor (TCR) therapies, resulting in clinically safe, effective, and re-dosable cell therapies. Triumvira is developing a pipeline targeting promising tumor-associated antigens such as Claudin 18.2, HER2, GUCY2C and GPC3. Triumvira has operations in San Diego, CA, Austin, Texas, and Hamilton, Ontario. For more information, visit us at or follow us on LinkedIn and X. Media Contact David Schull or Ignacio Guerrero-Ros, Ph.D. Russo Partners 858-717-2310 646-942-5604 [email protected] [email protected] SOURCE Triumvira Immunologics WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

SAN DIEGO and AUSTIN, Texas and HAMILTON, ON, Oct. 15, 2024 /PRNewswire/ -- Triumvira Immunologics, a clinical-stage company developing novel, targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with solid tumors, today announced the publication of a peer-reviewed article titled "Preclinical development of T cells engineered to express a T cell antigen coupler (TAC) targeting Claudin 18.2-positive solid tumors" in Cancer Immunology Research, a journal of the American Association for Cancer Research. The article, authored by a team of scientists led by Dr. Andreas Bader, Triumvira's Consulting Chief Scientific Officer, details the preclinical pharmacology and safety of TAC01-CLDN18.2, a novel autologous T cell therapy targeting Claudin 18.2 for the treatment of solid tumors. TAC01-CLDN18.2 is currently the subject of a clinical Phase I/II study (TACTIC-3, NCT05862324). "Our findings highlight the unique advantages of TAC01-CLDN18.2, which is designed to target and eliminate tumors with high specificity while minimizing the risk of adverse events that are commonly associated with T cell and other therapies," said Andreas Bader, Ph.D., Consulting Chief Scientific Officer of Triumvira Immunologics. "This research underscores our commitment to developing next-generation T cell therapies that are both effective and safe, and we are excited to continue exploring the clinical potential of TAC01-CLDN18.2 in treating patients with Claudin 18.2 positive solid tumors." "Publishing this research is a significant milestone for Triumvira, as it reinforces the potential of our TAC technology, currently in the clinic for Claudin 18.2 positive tumors, to transform the treatment landscape for cancer patients," said Robert Williamson, President of Triumvira Immunologics. "We remain committed to bringing innovative, life-saving treatments to patients in need, and this publication is a testament to the rigorous science in the company and dedication of our team." The study highlights the novel and proprietary T cell Antigen Coupler (TAC) technology from Triumvira Immunologics, a chimeric receptor that promotes tumor antigen-specific activation of T cells by leveraging the natural T cell receptor complex without causing tonic signaling. The preclinical results demonstrate that CLDN18.2-TAC T cells exhibit specific and durable anti-tumor activity across various in vitro and in vivo models of gastric, gastroesophageal, and pancreatic cancers. Importantly, the study reports high selectivity as these T cells did not induce notable off-target or on-target/off-tumor toxicities in these preclinical models, suggesting its potential safety and efficacy in clinical settings. Key Findings Specificity and Activity: TAC01-CLDN18.2 T cells demonstrated high specificity and potent cytotoxicity against Claudin 18.2 positive tumor cells in both 2D cultures and 3D tumor spheroids, including models with low antigen expression. CLDN18.2-TAC T vs CLDN18.2 CAR-T: In a head-to-head comparison against CLDN18.2-directed 2nd-generation CAR T cells, CLDN18.2-TAC T cells exhibited greater proliferative capacity, lower levels and delayed onset of T cell exhaustion, and overall greater and longer-lasting cytotoxicity in a recursive tumor cell killing assay. In Vivo Efficacy: In mouse models of gastric, gastroesophageal, and pancreatic cancers, TAC01-CLDN18.2 T cells effectively eradicated tumor xenografts, with durable efficacy observed in recursive killing and tumor rechallenge experiments. Safety Profile: The preclinical data showed that TAC01-CLDN18.2 T cells did not induce notable off-target or on-target/off-tumor toxicities, as these cells were unreactive to human cells representing vital organs. Durable Response: The research indicates that TAC01-CLDN18.2 T cells can induce a long-lasting anti-tumor response, supporting their potential as a safe and effective treatment for patients with Claudin 18.2 positive solid tumors. Full Publication Details Title: Preclinical development of T cells engineered to express a T cell antigen coupler (TAC) targeting Claudin 18.2-positive solid tumors Journal: Cancer Immunology Research Corresponding Authors: Andreas Bader, Ph.D., Christopher Helsen, Ph.D. Full Author List: Stacey Xu, Ling Wang, Philbert Ip, Ritu Randhawa, Tania Benatar, Suzanna Prosser, Prabha Lal, Alima Khan, Thanyashanthi Nitya-Nootan, Gargi Thakor, Heather MacGregor, Danielle Hayes, Andrea Vucicevic, Princy Mathew, Sadhak Sengupta, Christopher Helsen, and Andreas Bader The full research article can be accessed here. About Triumvira Immunologics Triumvira Immunologics, Inc. ("Triumvira") is a leading clinical-stage solid tumor cell therapy company developing unique, non-gene edited, first-in-class targeted autologous and allogeneic T cell therapeutics that co-opt the natural biology of T cells to treat patients with solid tumors. The company's proprietary T cell Antigen Coupler (TAC) technology platform activates natural T cell functions differently from other cell therapies such as CAR-T and engineered T cell receptor (TCR) therapies, resulting in clinically safe, effective, and re-dosable cell therapies. Triumvira is developing a pipeline targeting promising tumor-associated antigens such as Claudin 18.2, HER2, GUCY2C and GPC3. Triumvira has operations in San Diego, California, Austin, Texas, and Hamilton, Ontario. For more information, visit us at or follow us on LinkedIn and X. Media Contact David Schull or Ignacio Guerrero-Ros, Ph.D. Russo Partners 858-717-2310 646-942-5604 [email protected] [email protected] SOURCE Triumvira Immunologics WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED