Last update 08 May 2025

KRAS G12V/G12D targets TCR TCE (Affini-T)

Overview

Basic Info

Drug Type
Bispecific T-cell Engager (BiTE)
Synonyms-
Target
CD3 x KRAS G12D x KRAS G12V
Action
stimulants, inhibitors
Mechanism
CD3 stimulants(T cell surface glycoprotein CD3 stimulants), KRAS G12D inhibitors(GTPase KRas G12D inhibitors), KRAS G12V inhibitors(GTPase KRas G12V inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Solid tumor
Inactive Indication-
Originator Organization
Affini-T Therapeutics, Inc.Affini-T Therapeutics, Inc.
Active Organization
Affini-T Therapeutics, Inc.Affini-T Therapeutics, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Related

100 Clinical Results associated with KRAS G12V/G12D targets TCR TCE (Affini-T)
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100 Translational Medicine associated with KRAS G12V/G12D targets TCR TCE (Affini-T)
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100 Patents (Medical) associated with KRAS G12V/G12D targets TCR TCE (Affini-T)
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100 Deals associated with KRAS G12V/G12D targets TCR TCE (Affini-T)
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R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Solid tumorPreclinical
United States
Affini-T Therapeutics, Inc.Affini-T Therapeutics, Inc.
05 Nov 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Deal

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Clinical Trial

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Approval

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Biosimilar

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Competitive landscape of biosimilars in different countries/locations. Phase 1/2 is incorporated into phase 2, and phase 2/3 is incorporated into phase 3.

Regulation

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