Delving into the Latest Updates on XENON XE-127 with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms

XENON XE 127

Target-

Mechanism-

Therapeutic Areas-

Active Indication-

Inactive Indication-

Originator Organization

Mallinckrodt Medical, Inc.

Active Organization-

Inactive Organization

Mallinckrodt Medical, Inc. (US)

Drug Highest PhaseWithdrawn

First Approval Date

US (01 Oct 1982)

Regulation-

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PURPOSEThis study aimed to evaluate different deformable image registration (DIR) parameters for the open-source NiftyReg package in its application to DIR-based ventilation imaging.METHODSTwo three-dimensional (3D)-computed tomography (CT) scans of a non-rigid air-ventilating phantom were acquired at peak exhalation and peak inhalation, with xenon (Xe) gas being used as an air-based contrast agent. We compared four different sets of DIR parameters, including one set with two-step deformation and three sets with four-step deformation. For spatial accuracy, the target registration error (TRE) was calculated for 16 landmarks. For ventilation imaging accuracy, DIR-based ventilation images were generated using Jacobian determinant (JD) metrics, and changes in Hounsfield unit (HU) values between the two exhalation and inhalation CT images were subsequently measured. The correlation coefficients between the JD metrics and changes in HU values were calculated.RESULTSThe mean TRE values were 4.5 ± 4.7 mm (maximum, 12.3 mm), 1.47 ± 0.71 mm (maximum, 2.6 mm), 1.56 ± 0.70 mm (maximum, 2.8 mm), and 1.53 ± 0.66 mm (maximum, 2.5 mm) for the two-step deformation and three four-step deformations, respectively. The four-step deformations (R =  - 0.71, -0.65, and -0.61) showed stronger correlation coefficients than the two-step deformation (R =  -0.40).CONCLUSIONSThe accuracy of DIR-based ventilation imaging may vary with different DIR parameter settings, even though spatial accuracy may be tolerable and within guidelines. We found adequate parameter settings for four-step NiftyReg DIR for visualization of simulated pulmonary ventilation function.

100 Deals associated with XENON XE-127

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