Delving into the Latest Updates on Autologous Human C-Kit Cardiac Stem Cells (CSCs) II(University of Miami) with Synapse

Overview

Basic Info

Drug Type

Stem cell therapy

Synonyms-

Target-

Action-

Mechanism-

Therapeutic Areas

Cardiovascular Diseases

Active Indication-

Inactive Indication

Heart FailureMyocardial InfarctionVentricular Dysfunction, Left

Originator Organization

University of Miami

Active Organization-

Inactive Organization

University of Miami

License Organization-

Drug Highest PhaseDiscontinuedPhase 1/2

First Approval Date-

Regulation-

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A Phase I/II, Randomized, Placebo-Controlled Study of the Safety and Efficacy of Transendocardial Injection of Autologous Human Cells (Mesenchymal or the Combination of MSC and Cardiac Stem Cells) in Patients With Chronic Ischemic Left Ventricular Dysfunction and Heart Failure Secondary to Myocardial Infarction.

Before initiating the full randomized study, a Pilot Safety Phase will be performed. In this phase the composition of cells administered via the Biosense Webster MyoStar NOGA Injection Catheter System will be tested. The randomized portion of the study will be conducted after a full review of the safety data from the pilot Phase by the Data safety monitoring board.
Following the Pilot Phase of five (5) Fifty (50) patients scheduled to undergo cardiac catheterization and meeting all inclusion/exclusion criteria will be evaluated at baseline.
Patients will be randomized in a 2:2:1 ratio to one of three Treatment Strategies.

Start Date01 Mar 2025

Sponsor / Collaborator

University of Miami

100 Clinical Results associated with Autologous Human C-Kit Cardiac Stem Cells (CSCs) II(University of Miami)

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100 Translational Medicine associated with Autologous Human C-Kit Cardiac Stem Cells (CSCs) II(University of Miami)

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100 Patents (Medical) associated with Autologous Human C-Kit Cardiac Stem Cells (CSCs) II(University of Miami)

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100 Deals associated with Autologous Human C-Kit Cardiac Stem Cells (CSCs) II(University of Miami)

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R&D Status

10 top R&D records.

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Indication	Highest Phase	Country/Location	Organization	Date
Heart Failure	Phase 2	United States	University of Miami	01 Mar 2025
Myocardial Infarction	Phase 2	United States	University of Miami	01 Mar 2025
Ventricular Dysfunction, Left	Phase 2	United States	University of Miami	01 Mar 2025