Delving into the Latest Updates on Alpha-tocopheroloxyacetic acid (Veana Therapeutics) with Synapse

Overview

Basic Info

Drug Type

Therapeutic vaccine

Synonyms

Oral Vimo001, aTEA Veana Therapeutics, alfaTEA Veana Therapeutics

+ [1]

Target-

Action

stimulants

Mechanism

Apoptosis stimulants, Immunostimulants

Therapeutic Areas

NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases+ [1]

Active Indication-

Inactive Indication

Breast CancerCarcinomaLymphoma+ [1]

Originator Organization

Veana Therapeutics, Inc.

Active Organization-

Inactive Organization

Veana Therapeutics, Inc.

Providence Health & Services

License Organization-

Drug Highest PhasePendingPhase 1

First Approval Date-

Regulation-

Login to view timeline

The extractable activity of L-phenylalanine ammonia-lyase (EC 4.3.1.5) and the concentration of sugar esters of p-coumaric and ferulic acids in the hypocotyls of etiolated gherkin seedlings increase upon irradiation with white light. Treatment of intact seedlings with the phenylalanine ammonia-lyase inhibitors alpha-aminooxyacetic acid and L-alpha-aminooxy-beta-phenylpropionic acid during illumination causes enhanced formation of the lyase and reduces the accumulation of hydroxycinnamic acids. Enzyme activity in excised hypocotyl segments floating on buffer increases in the dark as well as in the light, while hydroxycinnamic acids accumulate only in the light. Phenylalanine ammonia-lyase formation in the segments is inhibited by cinnamic acid and, to a lesser extent, p-coumaric acid, while it is slightly enhanced by caffeic acid and is not affected by ferulic acid. Aminooxyphenylpropionate dramatically promotes phenylalanine ammonia-lyase formation in the segments in darkness and light prevents the accumulation of hydroxycinnamic acids in the light. Aminooxyphenylpropionate does not, however, affect the time course of apparent lyase formation and decay. Cinnamic acid, the product of the lyase reaction, antagonizes the effect of aminooxyphenylpropionate. It is proposed that the reaction product(s) are involved to some extent in the regulation of the pool of active lyase in the hypocotyl tissue.

100 Deals associated with Alpha-tocopheroloxyacetic acid (Veana Therapeutics)

Login to view more data

R&D Status

10 top R&D records.

Login

to view more data

Indication	Highest Phase	Country/Location	Organization	Date
Breast Cancer	Phase 1	United States	Veana Therapeutics, Inc.	07 Apr 2020
Carcinoma	Phase 1	United States	Veana Therapeutics, Inc.	-
Carcinoma	Phase 1	United States	Providence Health & Services	-
Lymphoma	Phase 1	United States	Veana Therapeutics, Inc.	-
Lymphoma	Phase 1	United States	Providence Health & Services	-
Sarcoma	Phase 1	United States	Providence Health & Services	-
Sarcoma	Phase 1	United States	Veana Therapeutics, Inc.	-