This case report, shows two cases of COVID-19 vaccine- related cutaneous allergic adverse reaction as a mild form of drug eruption.Case 1 a 48-yr- old female developed an erythematous eruption on the trunk and extremities 3 days after the second administration of BioNTech COVID-19 vaccine (Pfizer) without p.o. administration of acetaminophen or non- steroidal anti- inflammatory drugs (NSAIDs).Her skin eruption was rapidly improved by topical betamethasone propionate within 7 days of the treatment.Case 2 a 58- year-old female noticed itchy erythematous papules 4 days after the second BioNTech COVID- 19 vaccination (Pfizer) without p.o. administration of acetaminophen or NSAIDs.Her skin eruption was improved within 7 days of p.o. administration of an antihistamine drug and topical hydrocortisone butyrate.Although this case showed a mild form of drug eruption, further observational study is necessary to clarify the detailed characteristics of drug eruption by COVID- 19 vaccine.