Last update 08 May 2025

DB-3-291

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms-
Target
ABL2 x BLK x CSK x WEE1
Action
antagonists, inhibitors
Mechanism
ABL2 antagonists(ABL proto-oncogene 2, non-receptor tyrosine kinase antagonists), BLK inhibitors(BLK proto-oncogene, Src family tyrosine kinase inhibitors), CSK inhibitors(C-terminal Src kinase inhibitors)
+ [1]
Therapeutic Areas
Neoplasms
Active Indication-
Inactive Indication
Neoplasms
Originator Organization
Dana-Farber Cancer Institute, Inc.Dana-Farber Cancer Institute, Inc.Harvard Medical SchoolHarvard Medical School
Active Organization-
Inactive Organization
Dana-Farber Cancer Institute, Inc.Dana-Farber Cancer Institute, Inc.Harvard Medical SchoolHarvard Medical School
License Organization-
Drug Highest PhasePendingDiscovery
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC47H56ClN11O11S
InChIKeyJVHDDVDOQBLUTO-UHFFFAOYSA-N
CAS Registry-

Related

100 Clinical Results associated with DB-3-291
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100 Translational Medicine associated with DB-3-291
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100 Patents (Medical) associated with DB-3-291
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1
Literatures (Medical) associated with DB-3-291
01 Dec 2020CellQ1 · BIOLOGY
Mapping the Degradable Kinome Provides a Resource for Expedited Degrader Development
Q1 · BIOLOGY
100 Deals associated with DB-3-291
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeoplasmsDiscovery
United States
Dana-Farber Cancer Institute, Inc.Dana-Farber Cancer Institute, Inc.
01 Dec 2020
NeoplasmsDiscovery
United States
Harvard Medical SchoolHarvard Medical School
01 Dec 2020
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Approval

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Regulation

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