In comparison with other virus infections, such as HIV, HBV, HCV, influenza and herpes virus, dengue virus infections have received relatively little attention from a (chemo)therapeutic viewpoint, despite their global incidence (2.5 billion people estimated to be at risk) and absence of an effective prophylactic measure (i.e., vaccination). However, the replicative cycle of the dengue virus offers a wealth of potential target sites, including virus adsorption and fusion, RNA-dependent RNA polymerase (and the associated 2´-O-methyltransferase) and the N-glycosylation process. Numerous compounds have been identified that interfere with dengue virus infections (i.e., ribavirin, interferon, sulfated polysaccharides, 2´-C-methylnucleoside analogs and iminosugar derivatives). For other compounds found to be effective against the dengue virus, including geneticin (G418) and FGI-106, the mechanism of action still remains unresolved.

01 Sep 2009·Antiviral ResearchQ2 · MEDICINE

Development of a broad-spectrum antiviral with activity against Ebola virus

Q2 · MEDICINE

Article

Author: Michael Goldblatt ; Qingsong Tang ; Kelly Warfield ; Abdul Yunus ; Travis Warren ; Kevin Porter ; Sven Enterlein ; M. Javad Aman ; Peifang Wang ; Eric Stavale ; Michael S. Kinch ; Shaojing Chang ; Sina Bavari

We report herein the identification of a small molecule therapeutic, FGI-106, which displays potent and broad-spectrum inhibition of lethal viral hemorrhagic fevers pathogens, including Ebola, Rift Valley and Dengue Fever viruses, in cell-based assays. Using mouse models of Ebola virus, we further demonstrate that FGI-106 can protect animals from an otherwise lethal infection when used either in a prophylactic or therapeutic setting. A single treatment, administered 1 day after infection, is sufficient to protect animals from lethal Ebola virus challenge. Cell-based assays also identified inhibitory activity against divergent virus families, which supports a hypothesis that FGI-106 interferes with a common pathway utilized by different viruses. These findings suggest FGI-106 may provide an opportunity for targeting viral diseases.

100 Deals associated with FGI-106 series (Functional Genetics)

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Indication	Highest Phase	Country/Location	Organization	Date
Virus Diseases	Discovery	US	Functional Genetics, Inc.	-

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