Author: Rawle, Daniel J ; Yan, Kexin ; Suhrbier, Andreas ; Nakayama, Eri ; Hazlewood, Jessamine E ; Hall, Roy A ; Hobson-Peters, Jody ; Vet, Laura J ; Tang, Bing

Zika virus (ZIKV) is the etiological agent of congenital Zika syndrome (CZS), a spectrum of birth defects that can lead to life-long disabilities. A range of vaccines are in development with the target population including pregnant women and women of child-bearing age. Using a recently described chimeric flavivirus vaccine technology based on the novel insect-specific Binjari virus (BinJV), we generated a ZIKV vaccine (BinJ/ZIKA-prME) and illustrate herein its ability to protect against fetal brain infection. Female IFNAR−/− mice were vaccinated once with unadjuvanted BinJ/ZIKA-prME, were mated, and at embryonic day 12.5 were challenged with ZIKVPRVABC59. No infectious ZIKV was detected in maternal blood, placenta, or fetal heads in BinJ/ZIKA-prME-vaccinated mice. A similar result was obtained when the more sensitive qRT PCR methodology was used to measure the viral RNA. BinJ/ZIKA-prME vaccination also did not result in antibody-dependent enhancement of dengue virus infection or disease. BinJ/ZIKA-prME thus emerges as a potential vaccine candidate for the prevention of CSZ.

VaccinesQ3 · MEDICINE

The Chimeric Binjari-Zika Vaccine Provides Long-Term Protection against ZIKA Virus Challenge

Q3 · MEDICINE

ArticleOA

Author: Yan, Kexin ; Hazlewood, Jessamine E. ; Tang, Bing ; Rawle, Daniel J. ; Hobson-Peters, Jody ; Harrison, Jessica J. ; Hall, Roy A. ; Suhrbier, Andreas

We recently developed a chimeric flavivirus vaccine technology based on the novel insect-specific Binjari virus (BinJV) and used this to generate a chimeric ZIKV vaccine (BinJ/ZIKA-prME) that protected IFNAR-/- dams and fetuses from infection. Herein, we show that a single vaccination of IFNAR-/- mice with unadjuvanted BinJ/ZIKA-prME generated neutralizing antibody responses that were retained for 14 months. At 15 months post vaccination, mice were also completely protected against detectable viremia and substantial body weight loss after challenge with ZIKVPRVABC59. BinJ/ZIKA-prME vaccination thus provided long-term protective immunity without the need for adjuvant or replication of the vaccine in the vaccine recipient, both attractive features for a ZIKV vaccine.

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Indication	Highest Phase	Country/Location	Organization	Date
Zika Virus Infection	Preclinical	AU	QIMR Berghofer Medical Research Institute	02 Sep 2020

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