Delving into the Latest Updates on Phytoestrogen(CheBiGen) with Synapse

Overview

Basic Info

Drug Type

Small molecule drug

Synonyms-

Target

ER

Action

agonists

Mechanism

ERs agonists(Estrogen receptors agonists)

Therapeutic Areas

NeoplasmsSkin and Musculoskeletal Diseases

Active Indication-

Inactive Indication

Breast Cancer

Originator Organization

CheBiGen, Inc.

Active Organization-

Inactive Organization

CheBiGen, Inc.

License Organization-

Drug Highest PhasePendingDiscovery

First Approval Date-

Regulation-

Phytoestrogens are non-steroidal compounds that, can act as agonists and/or antagonists by binding to estrogen receptors; consequently they can modify estrogen-dependent processes of neonatal sexual differentiation. Results of the analysis of the sexual behavior of experimental rats that received 6.8 mg of isoflavones/kg/day, showed significantly more mating activity, but fewer ejaculations (p < 0.01), and a lower copulatory efficiency than the control group. Aggressive behavior was prominent in the phytoestrogen-treated males (p < 0.05), but defensive behavior was infrequent. Phytoestrogens may interfere with the development of male and female traits by competing with estradiol in contexts of sexual behavior. Compared to the control group, the phytoestrogen-treated males exhibited delayed olfactory perception and uncertain preference. The ventrolateral area of the medial hypothalamus is influenced by neonatal neuro estrogens that can produce changes in differentiation, such as the aggressiveness manifested by the males. A probable explanation is that this is due to the inhibition of aromatase by isoflavones. Regarding fertility, the females impregnated by the control males had more offspring (12.2 ± 2.10), than those of the experimental males (4.02 ± 1.13, p < 0.01). Spermatozoa analysis showed a low concentration (p < 0.05) due to isoflavone treatment, with increased immaturity (p < 0.01) and more dead spermatozoa (p < 0.05). We conclude that neonatal administration of genistein and daidzein alters olfactory functions, aggressiveness, sexual behaviors, and fertility through changes in spermatozoa quality. The most notable effect was the decreased of fertility in experimental male demonstrated by the lower number of pregnant females and smaller litters.

01 May 2025·CURRENT CARDIOLOGY REVIEWS

Unlocking the Potential: Phytoestrogens and Cardiovascular Health

Review

Author: Jain, Rohit ; Anamika, Fnu ; Banker, Himanshi ; Gulati, Arvind ; Muhammad, Alina Amin

Phytoestrogens are plant-derived compounds resembling human estrogen and have recently gained attention due to their potential role in improving cardiovascular health. These compounds exert their effects through various mechanisms, including interactions with estrogen receptors, growth factor receptors, inflammatory mediators, thrombogenic reactions, and apoptotic pathways. This results in cardioprotective effects like modulating endothelial function, decreasing vessel tone, reducing inflammation, altering lipid profiles, and influencing arrhythmogenesis. Recent studies indicate the intricate and multidimensional association between phytoestrogens and cardiovascular disease. Despite the overwhelming evidence that phytoestrogen intake lowers the risk of myocardial infarction (MI), prevents atherosclerosis, improves cardiac function, prevents hypertension, and reduces the risk of arrhythmias, there have been studies that show contradictory outcomes. For this reason, the therapeutic use of phytoestrogens for the treatment of cardiovascular diseases, which appears to be extremely promising, should be handled cautiously, considering the individual variances, dosage, and the specific components of phytoestrogens. This review consolidates findings on the effects of phytoestrogens on the heart and blood vessels, explores the mechanisms behind these interactions, and seeks to determine the best methods for using phytoestrogens as a supplement in managing and preventing cardiovascular disease. By understanding these aspects, we can better evaluate the potential of phytoestrogens in cardiovascular health and develop guidelines for their safe and effective use.

23 Apr 2025·CURRENT PHARMACEUTICAL DESIGN

Phytoestrogens: A Promising Therapeutic Approach for Endometriosis Management, Insights from Preclinical and Clinical Studies

Article

Author: Khazaei, Majid ; Avan, Amir ; Neykhonji, Marzieh ; Al-Asady, Abdulridha Mohammed ; Al-Nazwani, Nasser ; Al Okla, Souad ; Hassanian, Seyed Mahdi

Introduction::

Endometriosis is a prevalent gynecological disorder characterized by the growth of endometrial tissue outside the uterine cavity. The disease often involves internal organs and leads to chronic pelvic pain and infertility. While its pathogenesis remains incompletely understood, the disease is considered estrogen-dependent, and reducing estrogen levels is a primary clinical treatment strategy. Despite extensive research and diverse treatment modalities, including surgery and pharmacotherapy, current treatments are associated with significant complications and recurrence. This review aims to explore recent studies on phytoestrogens' therapeutic potential in endometriosis treatment by examining the underlying mechanisms contributing to their efficacy.

Methods::

An extensive evaluation of Google Scholar and PubMed, utilizing relevant keywords including "Endometriosis, Phytoestrogen, Estrogen, inflammation, pelvic pain, and Infertility" was carried out to assess the potential therapeutic efficacy of phytoestrogens in managing endometriosis, based on recent research findings. This review considered a wide range of studies, including in-vitro, in-vivo, and clinical studies, as well as reviews and research articles, to provide a comprehensive overview of the current state of knowledge on this topic.

Results::

Phytoestrogens, with their structural similarity to estrogen, have emerged as a novel therapeutic approach. These compounds compete for estrogen receptor binding, displaying anti-estrogenic or weak proestrogenic properties upon binding.

Conclusion::

Exhibiting anti-proliferative, antioxidant, anti-angiogenic, and pro-apoptotic properties, phytoestrogens have demonstrated substantial therapeutic potential in endometriosis management. Extensive cellular, animal, and clinical investigations support their therapeutic efficacy.

100 Deals associated with Phytoestrogen(CheBiGen)

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