Early sucking on a lollipop in the post-anesthesia care unit improves quality of recovery and satisfaction in children undergoing oral therapy under general anesthesia during the day: a prospective randomized controlled trial - Sucrose Lollipop Intervention on Postoperative Recovery in Children Undergoing Dental Treatment Under General Anesthesia: A Randomized Controlled Trial

Start Date24 Mar 2025

Sponsor / Collaborator-

NCT06799715

/ RecruitingNot Applicable

Assessments of Metabolic Responses to Acute Oral Administration of Sucrose, Glucose, and Fructose in Healthy Humans

This project aims to compare the acute metabolic effects of the three sweeteners sucrose, glucose, and fructose on GI hormones (GLP-1, PYY, CCK, and ghrelin).
Furthermore, glycemic control, erythritol and xylitol concentrations, blood coagulation function , blood lipids, uric acid, high-sensitive C-reactive protein (hsCRP), complete blood count, gastric emptying, appetite-related sensations, and GI symptoms will be investigated.

Start Date06 Feb 2025

Sponsor / Collaborator-

NCT06641687

/ RecruitingNot ApplicableIIT

Oral Sucrose for Pain Management During Flexible Nasolaryngoscopy

The investigators want to know if sugar water containing 24% sucrose is helpful in reducing pain in babies during scopes.

Start Date23 Sep 2024

Sponsor / Collaborator

The Hospital for Sick Children

100 Clinical Results associated with Sucrose

100 Translational Medicine associated with Sucrose

100 Patents (Medical) associated with Sucrose

151,751

Literatures (Medical) associated with Sucrose

31 Dec 2025·Italian Journal of Animal Science

Effects of pollen enriched diet on hypopharyngeal glands’ morphology and morphometry and vitellogenin transcription levels in honey bees

Author: Maiolino, Paola ; Valenzano, Viviana ; Power, Karen ; D’Emilio, Claudia ; Di Prisco, Gennaro ; Martano, Manuela

Pollen-enriched diets can increase the size and functionality of HPGs improving honey bee health and productivityTranscriptional levels of VG showed that it varied significantly over time but was independent of the tested diets

01 Dec 2025·Tropical Plant Biology

An Overview of UDP-Glucose Pyrophosphorylase in Plants

Author: Wenqi, Zhang ; Zhang, Wenqi

A review.Uridine diphosphate-glucose (UDP-Glc) plays a pivotal role as an essential precursor in cytoplasmic sucrose biosynthesis and provides Glc as a critical building block for synthesizing various macromols. such as polysaccharides, proteins, and lipids through glycosylation reactions.These include the synthesis of cellulose, hemicellulose, and cell wall polysaccharides.Moreover, UDP-Glc acts as a signaling mol. implicated in both biotic and abiotic stress responses by triggering the MAP kinase cascade and ROS signaling pathways.The synthesis of UDP-Glc in plants is primarily catalyzed by the UDP-Glc pyrophosphorylase (UGPase) enzyme, exhibiting tissue-specific variations in catalytic direction.In source tissues such as leaves, UGPase uses Glucose-1-phosphate (Glc-1-P) and UTP as substrates to produce UDP-Glc and PPi.In non-photosynthetic sink tissues, UGPase catalyzes a pyrophospholytic reaction on UDP-Glc to Glc-1-P for the demand of metabolic processes.Plants possess two distinct types of UGPases, UGPase-A and UGPase-B.The former has an approx. mol. weight of 50-55 kDa and predominantly localizes within the cytoplasm, while the latter weighs around 90 kDa and resides within chloroplasts.UGPase exists in both monocotyledonous and dicotyledonous plants, functioning as monomers when active.The UGPase gene family in plants typically consists of a number of two or three genes, encoding two types of UGPases.Deficiency in UGPase leads to growth inhibition, developmental constraints, reduced levels of soluble sugars and starch, impaired callose deposition in pollen resulting in male sterility, and compromised cell wall integrity.Conversely, overexpression of the UGPase gene promotes accelerated growth rate, increased plant height, significantly elevated levels of soluble sugars and cellulose content, as well as enhanced stress tolerance.Consequently, UGPase emerges as a promising candidate gene for agricultural improvement.

01 Dec 2025·Rice

Unelongated Stems are an Active Nitrogen-Fixing Site in Rice Stems Supported by Both Sugar and Methane Under Low Nitrogen Conditions

Article

Author: Nishiwaki, Reo ; Hotta, Yukina ; Nishihara, Arisa ; Kondo, Motohiko ; Sasaki, Ryosuke ; Masuda, Yoko ; Shinjo, Rina ; Hirai, Masami Yokota ; Okamoto, Takanori ; Sugiura, Daisuke ; Miyado, Sota

Enhancing nitrogen (N) fixation in rice plants can reduce N fertilizer application and contribute to sustainable rice production, particularly under low-N conditions. However, detailed microbial and metabolic characterization of N fixation in rice stems, unlike in the well-studied roots, has not been investigated. Therefore, the aim of this study was to determine the active N-fixing sites, their diazotroph communities, and the usability of possible carbon sources in stems compared with roots. The N-fixing activity and copy number of the nitrogenase gene in the rice stem were high in the outer part of the unelongated stem (basal node), especially in the epidermis. N fixation, estimated using the acetylene reduction assay, was also higher in the leaf sheath and root than in the inner part of the unelongated stem and culm. Amplicon sequence variants (ASVs) close to sugar-utilizing heterotrophic diazotrophs belonging to Betaproteobacteria and type II methanotrophic diazotrophs belonging to Alphaproteobacteria were abundant in the outer part of the unelongated stems. Media containing crushed unelongated stems exhibited N-fixing activity when sucrose, glucose, and methane were added as the sole carbon sources. This suggested that N fixation in the unelongated stems was at least partly supported by sugars (sucrose and glucose) and methane as carbon sources. ASVs close to sugar-utilizing heterotrophs belonging to Actinobacteria were also highly abundant in the unelongated stem; however, their functions need to be further elucidated. The present finding that diazotrophs in rice stems can use sugars such as sucrose and glucose synthesized by rice plants provides new insights into enhancing N fixation in rice stems.

News (Medical) associated with Sucrose

08 Aug 2024

·www.drugs.com

More Evidence That an Artificial Sweetener Poses Heart Risk

THURSDAY, Aug. 8, 2024 -- There's more evidence to suggest that the common artificial sweetener erythritol might pose dangers to consumers' hearts. The new study, involving 20 healthy adult volunteers, found that at doses commonly found in an erythritol-sweetened soda or muffin, the sweetener was linked to heightened activity of blood platelets, which could make clots more likely. No such effect was seen with sugar, noted a team led by Dr. Stanley Hazen , chair of cardiovascular and metabolic sciences at the Cleveland Clinic’s Lerner Research Institute. “Many professional societies and clinicians routinely recommend that people at high cardiovascular risk -- those with obesity, diabetes or metabolic syndrome -- consume foods that contain sugar substitutes rather than sugar,” Kazen explained in a clinic news release. However, his team's findings "underscore the importance of further long-term clinical studies to assess the cardiovascular safety of erythritol and other sugar substitutes," Kazen said. The findings were published Aug. 8 in the journal Arteriosclerosis, Thrombosis and Vascular Biology . The new study comes more than a year after Hazen's team published similar results in the journal Nature Medicine . As reported last year by HealthDay , that study of nearly 1,200 people found those who had large amounts of erythritol in their blood were up to twice as likely to suffer a heart attack or stroke compared to those with the least amounts. At the time, a lab investigation had hinted that erythritol produced this harmful effect on the heart by stimulating clot-forming platelets. Erythritol is about 70% as sweet as sugar and is produced commercially by fermenting corn. It’s found in many keto foods and zero-sugar foods, Hazen said, and is an ingredient in some Splenda stevia sweetener products and Truvia. “It's literally one of the fastest-growing artificial sweeteners in processed foods,” Hazen said when the Nature Medicine study was published. “We make it ourselves in our body, but at an amount that is a thousand to a million-fold less than what it is when we ingest it in an artificially sweetened product that has it.” In the new study, 20 healthy volunteers were given a dose of erythritol equivalent to that found in a sugarless muffin or can of diet soda. Blood levels of erythritol rose 1,000-fold soon after, the researchers found, and that was accompanied by a big rise in a blood clot formation among the volunteers. “This research raises some concerns that a standard serving of an erythritol-sweetened food or beverage may acutely stimulate a direct clot-forming effect,” said study co-author Dr. W. H. Wilson Tang , research director for Heart Failure and Cardiac Transplantation Medicine at Cleveland Clinic. “Erythritol and other sugar alcohols that are commonly used as sugar substitutes should be evaluated for potential long-term health effects, especially when such effects are not seen with glucose itself.” Erythritol is classified by the U.S. Food and Drug Administration as “generally recognized as safe." According to Hazen's group, that's largely because erythritol is a sugar alcohol found naturally in fruits and vegetables and "a byproduct of glucose metabolism in human tissue, although in small quantities." However, according to Hazen, the combined data from his team's studies should give weight-conscious consumers pause. “I feel that choosing sugar-sweetened treats occasionally and in small amounts would be preferable to consuming drinks and foods sweetened with these sugar alcohols, especially for people at elevated risk of thrombosis such as those with heart disease, diabetes or metabolic syndrome,” Hazen advised. “Cardiovascular disease builds over time, and heart disease is the leading cause of death globally. We need to make sure the foods we eat aren’t hidden contributors.” The study was supported in part by U.S. National Institutes of Health and the Office of Dietary Supplements. A group representing the sweetener industry questioned the study's methodology. The findings should be interpreted with "extreme caution," Calorie Control Council President Carla Saunders ‎told CBS News. She pointed to the limited number of participants and "excessive amount" of erythritol, which she said was "nearly double to triple the maximum amount approved in any single beverage in the United States based on standard 8-16oz serving." "Importantly, erythritol levels were only measured once after consumption, and the pilot lacked control over lifestyle factors that may affect the outcome, which could introduce confounding variables and impact the reliability of the findings," the statement continued. "Further, as erythritol levels were only measured at baseline and 30 minutes after consumption, there is no way to demonstrate any lasting effect of excessive consumption on any health outcome. Consumers need to rely on science, and for 30 years, science has shown that erythritol is a proven safe and effective choice for sugar and calorie reduction." Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.

11 Mar 2024

·www.prnewswire.com

Tagatose Becomes First Sweetener and Ingredient to Earn NutraStrong™ Prebiotic Verified Certification

WEST PALM BEACH, Fla., March 11, 2024 /PRNewswire/ -- Tagatose, a monosaccharide that has gained popularity for its ability to meet calorie-reduction targets without compromising taste, texture or function, is now the first sweetener to attain the NutraStrong™ Prebiotic Verified certification. Continue Reading Tagatose Bonumose, Inc., a producer of tagatose, and ASR Group, its distributor, are proud to announce that tagatose is also the first ingredient to earn this prebiotic certification. This independent endorsement further establishes tagatose as an ideal ingredient for food, beverage and nutraceutical manufacturers seeking sweetener solutions that meet consumer demand for functional, lower-calorie products. As the global appetite for improved gut health continues to grow, demand for prebiotics is increasing because of the important role they play in nourishing beneficial gut bacteria and promoting digestive health. In fact, according to Innova Market Insights, new product launches featuring prebiotic ingredients enjoyed a 6% CAGR between 2017-2023. "Today's consumers want their foods and beverages to work harder for them, so it's no surprise they're seeking prebiotic ingredients," said Karen Weikel, Ph.D., Director of Nutrition Science at Bonumose. "Tagatose is a revolutionary product, because for the first time, we can offer manufacturers a sweetener solution that provides prebiotic benefits, while maintaining the sweetness consumers desire." NutraStrong™ Prebiotic Verified is an industry-spanning program that classifies products with relevant and specific standards for each product category. These standards set a baseline of quality and testing to ensure the market is providing customers with quality prebiotic products. "Bonumose's commitment to both the quality and science required for prebiotic certification serve as an example for the industry," said Kevin Yan, Vice President of Certifications and Analytics at SGS Nutrasource, the company that administers NutraStrong™ certification. "By becoming a certified ingredient, Bonumose gained access to the Prebiotic Certified program for all products utilizing their tagatose. This access gives brands the ability to certify and promote their own usage of tagatose, highlighting the benefits of such quality ingredients." "When the Global Prebiotic Association conceived of the Prebiotic Verified program as part of the NutraStrong™ umbrella, it was to create a reward for suppliers and brands with substantiated prebiotic products - those that invested in quality and science and those that formulated wisely," said Len Monheit, Executive Director of the Global Prebiotic Association. "We are truly excited that the inaugural ingredient through the program is tagatose and that the NutraStrong™ Prebiotic Verified program now includes an ingredient that brands can leverage." Tagatose's prebiotic properties are just one of the many benefits it provides to manufacturers. Compared to sucrose, tagatose is 90% as sweet with 60% fewer calories. It tastes and performs similar to sucrose across a wide variety of applications. Because it has a low glycemic index of 3, tagatose does not raise blood glucose levels when consumed on its own. It is also Ketogenic Certified, Non-GMO Project Verified and Plant-Based Certified. "We believe it's important to provide manufacturers with a variety of sweeteners to meet all of their needs," said Jim Kappas, Vice President of Specialty Ingredients at ASR Group. "Tagatose is a fitting solution for manufacturers who seek to make every calorie count with ingredients that taste great and provide functional benefits." ASR Group will be exhibiting at Natural Products Expo West 2024, March 13-16 in Anaheim, Calif. Attendees interested in learning more about the benefits of tagatose and sampling gummies made with tagatose can visit ASR Group at booth #1013. To learn more about tagatose, visit . Customers may request tagatose samples via this online form. Please contact Lisa Ptak at [email protected] to schedule appointments with ASR Group at Natural Products Expo West. About ASR Group ASR Group International, Inc. (ASR Group) is the world's largest refiner and marketer of cane sugar, with an annual production capacity of more than 6 million tons of sugar. The company produces a full line of grocery, industrial, food service and specialty sweetener products. Across North America, ASR Group owns and operates six sugar refineries, located in New York, California, Maryland, Louisiana, Canada and Mexico. In Europe, the company owns and operates sugar refineries in the United Kingdom, Portugal, and, with a joint venture partner, Italy. ASR Group also farms sugarcane and owns sugar mills in Mexico and Belize. The company's portfolio includes the leading brands Domino®, C&H®, Florida Crystals®, Redpath®, Tate & Lyle®, Lyle's®, Sidul® and Tellus®. ASR Group is owned by Florida-based cane sugar producers Florida Crystals Corporation and Sugar Cane Growers Cooperative of Florida. ASR Group and its parent companies jointly own Tellus Products, LLC, a maker of single-use, compostable tableware and foodservice products from sugarcane and other plant fibers. For more information, visit . About Bonumose, Inc. Bonumose, Inc. ( ) is an early-stage food ingredient and enzyme innovation company based in Albemarle County, Virginia. Bonumose is supported by global strategic investors and "food for health"-focused institutional investors, and an expanding network of global collaboration partners across the value chain. Bonumose developed and patented the methods for continuous production of high-purity rare sugars – such as Tagatose and Allulose – from low-cost, plant-based starch. Bonumose's cost-advantaged processes make possible the global mass-market adoption of healthy, great-tasting, fully-functional rare sugars. Bonumose also can upcycle by-product/sidestream starch left over from its supply chain partners' food production. Beyond food ingredients, Bonumose also is developing enzyme solutions for dietary supplements, crop protection, animal nutrition, and other globally-significant industries. Bonumose operates with a philosophy of Business as a Moral Imperative. About SGS Nutrasource Pharmaceutical and Nutraceutical Services Inc. SGS Nutrasource is a leading nutraceutical and pharmaceutical life sciences company focused on helping clients commercialize health and wellness products. In addition to a unique offering of clinical trial management, strategic and regulatory support services along with a state-of-the-art clinical trial site, SGS Nutrasource offers a series of third-party natural ingredient product certification programs (NutraStrong™, IFOS™, IKOS™, IGEN™, and IPRO™. SOURCE ASR Group

10 Aug 2023

·www.prnewswire.com

China Gaotang: Extending the Industrial Chain and Accelerating the Cultivation of Clusters

LIAOCHENG, China, Aug. 10, 2023 /PRNewswire/ -- This is a report from the Shandong office of Hong Kong Business Daily. Gaotang County, Shandong Province has solidly promoted new breakthroughs in major industrial projects and made every effort to push project construction work to a new level. This year, Shandong Aobo Biotechnology Co., Ltd., with a total investment of 150 million yuan, has entered the formal production stage of the biological enzyme production of aloketose project in Gaotang County. The project can achieve an annual sales revenue of 800 million yuan and profits and taxes of over 60 million yuan, injecting new momentum into the transformation of the enterprise into the biopharmaceutical health sector. The aloketose produced by the enterprise is a new type of functional monosaccharide with special health functions, with a sweetness equivalent to 70% of sucrose, zero sugar, zero fat, and zero calories. It has a promoting and protective effect on pancreatic islet cells, has similar taste and volume characteristics to sucrose, and can also react with amino acids or proteins in food in a Maillard manner. It is the ideal substitute for sucrose, with broad market prospects. Introduction by Wang Shuhua, Director of the R&D Center of Octopus Group. Adhere to high standard planning and continuously expand industrial clusters. Since the beginning of this year, Gaotang has implemented 57 key projects with a total investment of 24.834 billion yuan. Focusing on leading industrial chains such as equipment manufacturing, health food, paper and printing, we will make up for the shortcomings of the industrial chain, stretch the industrial chain, accelerate the cultivation of "wild goose formation" clusters and characteristic industrial clusters, and strive to form a group of industrial clusters with long product chains and strong industrial clustering. "Dynamically follow up on the construction status of existing key projects, promptly analyze and judge the existing difficulties and blockages in the same location, play the role of linkage service mechanism, organize relevant units to discuss, and strive to solve them in the shortest possible time. "Guo Chao, a member of the Party Group and Deputy Director of the Gaotang County Development and Reform Bureau, said. As of the end of June, 10 provincial-level key projects in Gaotang County have completed a cumulative investment of 1.425 billion yuan, and 17 municipal level key projects have completed a cumulative investment of 1.622 billion yuan. SOURCE Shandong Office of Hong Kong Business Daily

100 Deals associated with Sucrose

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KEGG	Wiki	ATC	Drug Bank
D00025	Sucrose	-	DB02772

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Indication	Highest Phase	Country/Location	Organization	Date
Bacterial Vaginosis	NDA/BLA	China	Shenzhen Funuo Bio-Technology Co., Ltd.	29 Sep 2009
Bacterial Vaginosis	NDA/BLA	China	Biomedical Engineering Centre Of Hebei Medical University	29 Sep 2009

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Study	Phase	Population	Analyzed Enrollment	Group	Results	Evaluation	Publication Date


ASN2021	Not Applicable	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	36	Non-sucrose containing IVIG	ijdsnmdwtl(melpevztoj) = cbaeggjfxf pjxqkjorxw (rasktqryzp, 88 - 159)	Positive	27 Oct 2021
				Sucrose containing IVIG	ijdsnmdwtl(melpevztoj) = glpycmasoh pjxqkjorxw (rasktqryzp, 86 - 173)
NCT01438008 (CTgov)	Phase 4	Pain	9	24% sucrose po solution (Sucrose 24% po)	najtdfrdwz(oqrgwrkbbv) = uzdypqlbyr ygjdbknket (wxlyqvbvoe, rtmgtojlvj - wddxqmoeum) View more	-	19 Oct 2020
				Placebo po (Placebo po)	najtdfrdwz(oqrgwrkbbv) = xttcsttksg ygjdbknket (wxlyqvbvoe, opvcdxvjiw - pktceogzsk) View more
P0647 (ERA2020)	Not Applicable	Acute Kidney Injury Cyclosporine levels \| serum creatinine \| urinalysis ... View more	-	Sucrose-containing IVIG	ewbsqxazdl(lalttaumam) = The patient subsequently developed acute kidney injury. The outcome was favorable with recovery of filtration rate to the baseline within 21 days without the need for dialysis. sezytbqcbe (ajhktoebhj ) View more	Negative	06 Jun 2020
SFN2014	Not Applicable	Binge-Eating Disorder	-	sucrose (Intermittent (INT/BINGE))	fsomkuaipn(dcqgbgtckl) = AL’s evoked by taste cues was concentration-dependent and was significantly lesser only for the INT/BINGE group relative to AdL and CH group ltznkvhofg (cedpkgmbqy ) View more	-	16 Nov 2014
				sucrose (Chow (CH))
ARVO2005	Not Applicable	Corneal Endothelial Cell Loss	-	Sucrose (hypo-osmotic balanced salt solution (BSS))	xzzjvnpmcx(qiypiynvgf) = njhotsocju zmkuapubcy (tyhotnrcas, 288)	-	01 May 2005

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