Last update 11 Jul 2025

XY-4-88

Overview

Basic Info

Drug Type
Proteolysis-targeting chimeras (PROTAC)
Synonyms
Compound 13(Dana-Farber Cancer Institute), XY-4-88
Target
KRAS G12C
Action
degraders, inhibitors
Mechanism
KRAS G12C degraders(GTPase KRas G12C degraders), KRAS G12C inhibitors(GTPase KRas G12C inhibitors)
Therapeutic Areas
Neoplasms
Active Indication
Neoplasms
Inactive Indication-
Originator Organization
Dana-Farber Cancer Institute, Inc.Dana-Farber Cancer Institute, Inc.
Active Organization
Dana-Farber Cancer Institute, Inc.Dana-Farber Cancer Institute, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC48H50ClFN10O6
InChIKeyHIBGKXYCBQYVSE-UHFFFAOYSA-N
CAS Registry-

Related

100 Clinical Results associated with XY-4-88
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100 Translational Medicine associated with XY-4-88
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100 Patents (Medical) associated with XY-4-88
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100 Deals associated with XY-4-88
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
NeoplasmsPreclinical
United States
Dana-Farber Cancer Institute, Inc.Dana-Farber Cancer Institute, Inc.
26 Dec 2019
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date

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Deal

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Core Patent

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Clinical Trial

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Approval

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Regulation

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