Author: Watanabe, Mirian ; Couto, Sheila Marques Fernandes ; Borges, Fernanda Teixeira ; Santos, Alef Aragão Carneiro Dos ; Vattimo, Maria de Fatima Fernandes ; Fonseca, Cassiane Dezoti da

OBJECTIVESContrast-induced acute kidney injury (CI-AKI) is an important clinical problem that can be aggravated by diabetes mellitus, a major risk factor. However, heme oxygenase-1 (HO-1), a promising therapeutic target, can exert antioxidant effects against CI-AKI. Thus, we investigated the role of HO-1 in CI-AKI in the presence of diabetes mellitus.METHODSTwenty-eight male Wistar rats weighing 250-300g were subjected to left uninephrectomy, and concomitantly, diabetes induced by streptozotocin (65 mg/kg). After 12 weeks, iodinated contrast (meglumine ioxithalamate, 6 mL/kg) and hemin (HO-1 inducer-10 mg/k) were administered 60 min before iodinated contrast treatment. The rats were randomly divided into four groups: control, diabetes mellitus (DM), DM iodinated contrast (DMIC), and DMIC hemin (DMICH). Kidney function, albuminuria, oxidative profile, and histology were assessed. All experimental data were subjected to statistical analyses.RESULTSCI-AKI in preclinical diabetic models decreased creatinine clearance and increased urinary neutrophil gelatinase-associated lipocalin (NGAL) levels and the degree of albuminuria. Additionally, the levels of oxidative and nitrosative stress metabolites (urinary peroxides, thiobarbituric acid-reactive substances, and NO) were elevated, while thiol levels in kidney tissue were reduced. Kidney histology showed tubular cell vacuolization and edema. HO-1 inducer treatment improved kidney function and reduced urinary the NGAL levels. The oxidative profile showed an increase in the endogenous thiol-based antioxidant levels. Additionally, the tubular injury score was reduced following HO-1 treatment.CONCLUSIONSOur findings highlight the renoprotective effects of HO-1 in CI-AKI and preclinical diabetic models. Therefore, HO-1 ameliorates kidney dysfunction, reduces oxidative stress, and prevents cell necrosis.

17 Nov 2020·BioMed Research InternationalQ3 · BIOLOGY

Physical Training Is a Potential Modifier of Risk for Contrast-Induced Acute Kidney Injury in Diabetes Mellitus

Q3 · BIOLOGY

ArticleOA

Author: Silva, Vinicius C. ; Machado, Douglas I. ; Brandi, Beatriz A. ; Peres, Karina B. ; Souza, Adriana A. ; Conde, Carolina ; Couto, Sheila M. F. ; Vattimo, Maria De Fátima F.

Background. Iodinated contrast (IC) is a leading cause of hospital-based acute kidney injury (AKI). Contrast-induced acute kidney injury (CI-AKI) is a decline in renal function due to iodinated contrast administration and occurs more frequently in individuals with increasingly common risk factors, such as diabetes mellitus (DM). Physical training (PT) can have renoprotective effects on CI-AKI in diabetic nephropathy. The aim of this study was to evaluate the injury in kidneys of diabetic rats submitted to treatment with IC, evaluating the impact of PT on hemodynamics and renal function in addition to oxidative profile in diabetic rats submitted to IC-AKI. Materials and Methods. Adult male Wistar rats are randomized into four groups: citrate (

n = 7

): control group, citrate buffer (streptozotocin-STZ vehicle), intravenous tail (iv), single dose; DM (

n = 7

): STZ, 60 mg/kg, iv, single dose; DM+IC (

n = 7

): DM rats treated with IC (sodium meglumine ioxithalamate, 6 mL/kg, intraperitoneal (ip), single dose); DM+IC+PT (

n = 7

): DM rats treated with IC as mentioned and submitted to physical training. Renal function parameters (inulin clearance, neutrophil gelatinase-associated lipocalin (NGAL), serum creatinine, and urinary albumin), hemodynamics (renal blood flow and renal vascular resistance), and oxidative profile (urinary peroxides, urinary TBARS, urinary nitric oxide, and renal tissue thiols) were evaluated. Results. It was possible to observe a decrease in inulin clearance, renal blood flow, and thiols in renal tissue accompanied by an increase in urinary flow, serum creatinine, urinary albumin, renal vascular resistance, urinary peroxides, urinary nitrate, and TBARS in the DM group compared to the citrate group. The DM+IC group showed a reduction in inulin clearance, and the renal dysfunction was also seen by the increased NGAL. Renal hemodynamics and oxidative profile compared were also worsened in the DM group. PT improved renal function by increasing renal blood flow and thiol levels in renal tissue and reduced renal vascular resistance, metabolites of reactive oxygen, nitrogen species, and lipid peroxidation in the DM+IC+PT group compared to DM+IC. Conclusions. Our results confirmed that DM induction increases renal vulnerability to the toxicity of IC and an association between DM with IC predisposes to severe AKI with reduced renal function alongside with renal hemodynamic alterations and oxidative mechanism of injury. The PT showed a renoprotective effect in DM animals subjected to damage with IC by modulating renal hemodynamics and oxidative profile, confirming a potential to modify the risk of CI-AKI when diabetes mellitus is present.

01 May 2020·Hepatology ResearchQ3 · MEDICINE

Improved visualization of a fine intrahepatic biliary duct on drip infusion cholangiography‐computed tomography: Impact of knowledge‐based iterative model reconstruction

Q3 · MEDICINE

Article

Author: Yoshizumi, Tomoharu ; Kakihara, Daisuke ; Nakayama, Tomohiro ; Asayama, Yoshiki ; Ikegami, Toru ; Ishimatsu, Keisuke ; Fujita, Nobuhiro ; Honda, Hiroshi ; Ushijima, Yasuhiro ; Morita, Koichiro ; Nishie, Akihiro ; Kondo, Masatoshi ; Ishigami, Kousei ; Takao, Seiichiro

AimThe purpose of this study was to investigate the visualization of fine biliary ducts with knowledge‐based iterative model reconstruction (IMR) in low‐dose drip infusion computed tomography (CT) cholangiography (DIC‐CT) as compared with filtered back projection (FBP) and hybrid iterative reconstruction (iDose4).MethodsA total of 38 patients underwent DIC‐CT for living donor liver transplantation. CT was performed approximately 20 min after the end of the infusion of meglumine iotroxate (100 mL). Images were reconstructed using FBP, iDose4, and IMR, and 1‐mm slice images at fixed window level and width were prepared for assessment. Two reviewers independently evaluated the quality of visualization of the fine biliary ducts of the caudate lobe (B1) using a 5‐point scale. The visualization scores of three reconstructed images were compared using the Kruskal–Wallis test and Mann–Whitney U‐test.ResultsFor reviewer 1, the visualization score of IMR was significantly higher than that of FBP (P = 0.012), and tended to be higher than that of iDose4 (P = 0.078). For reviewer 2, the visualization score of IMR was significantly higher than those of both FBP and iDose4 (P < 0.01).ConclusionsIMR showed better visualization of B1 on DIC‐CT than FBP or iDose4. DIC‐CT reconstructed with IMR may be useful to the anatomical grasp of biliary tracts in cases of hepatectomy.

100 Deals associated with Iothalamate Meglumine

External Link

KEGG	Wiki	ATC	Drug Bank
D01999	Iothalamate Meglumine	V08AA04	DB09133

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10 top approved records.

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Indication	Country/Location	Organization	Date
Cerebrovascular Disorders	US	Liebel-Flarsheim Co. LLC	16 Aug 1962
Contrast agents	US	Liebel-Flarsheim Co. LLC	16 Aug 1962
Peripheral Arterial Disease	US	Liebel-Flarsheim Co. LLC	16 Aug 1962
Urethral Diseases	US	Liebel-Flarsheim Co. LLC	16 Aug 1962

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