Delving into the Latest Updates on Autologous Stem Cells(El-Rayadh Fertility Centre) with Synapse

Overview

Basic Info

Drug Type

Stem cell therapy

Synonyms-

Target-

Mechanism

Stem cell replacements

Therapeutic Areas

Endocrinology and Metabolic DiseaseUrogenital Diseases

Active Indication-

Inactive Indication

Arrest of SpermatogenesisPrimary Ovarian Insufficiency

Originator Organization

El-Rayadh Fertility Centre

Active Organization-

Inactive Organization

El-Rayadh Fertility Centre

Drug Highest PhasePendingPhase 1/2

First Approval Date-

Regulation-

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The diabetic fot/ulcer is the cause of high morbidity and mortality in patients with diabetes mellitus (DM). Generally, medical treatment of diabetic foot/ulcer is ineffective and stem cell implantation is an important option in the treatment. Here, we present a 69 years old man admitted to hospital due to a 3 × 4 cm wound in the plantar surface of left foot. Autologous stem cells were applied intralesionally into diabetic ulcers. The lesion shrunken 50 % at the 16th week and there is a wound under the left foot at 32nd week. Intralesionally autologous stem cell application was useful and safe without adverse course in patients with diabetic foot/ulcer.

01 Apr 2011·Gastrointestinal endoscopyQ1 · MEDICINE

Use of adipose tissue-derived stromal cells for prevention of esophageal stricture after circumferential EMR in a canine model

Q1 · MEDICINE

Article

Author: Michitaka Honda ; Hidenori Shimada ; Masato Uji ; Kazumichi Yamamoto ; Tatsuo Nakamura ; Takeshi Kobayashi ; Yuji Nishizawa ; Akira Nakada ; Toshihiko Sato ; Yoshio Hori ; Naoki Kida

BACKGROUND:

EMR is an accepted treatment for early esophageal carcinoma. However, resection of a large mucosal area often causes postoperative esophageal stricture.

OBJECTIVE:

To investigate the efficacy of autologous adipose tissue-derived stromal cells (ADSCs) for prevention of stricture formation after EMR in dogs.

DESIGN:

Animal study.

SETTING:

University research center.

INTERVENTION:

Ten beagle dogs were randomized into a control group and an ADSCs-injected (ADSC) group. The ADSCs were isolated from autologous adipose tissue. Immediately after circumferential esophageal EMR, about 5 × 10(6) ADSCs suspended in 8 mL of phosphate-buffered saline solution were injected endoscopically into the residual submucosa of the ADSC group, whereas the control group received only 8 mL of phosphate-buffered saline solution.

MAIN OUTCOME MEASUREMENTS:

Dysphagia score, weight loss, rate of mucosal constriction, and histologic assessments.

RESULTS:

In the control and ADSC groups, the median dysphagia scores were 4 and 1 (P < .043), the mean degrees of mucosal constriction were 75.7% and 45.3% (P < .008), and the numbers of nascent microvessels in the submucosal layer were 7.4 and 16.2 per unit area (P = .007), respectively. Atrophy and fibrosis of the muscularis propria layer were observed in the control group.

LIMITATIONS:

Animal study, small sample size.

CONCLUSION:

Injection therapy with autologous ADSCs suppresses constriction of the esophageal mucosa and improves clinical symptoms after circumferential EMR in this canine model.

01 Mar 2010·Journal of gastrointestinal cancer

Stem Cell Therapy Improves the Outcome of Liver Resection in Cirrhotics

Article

Author: Ossama Fouad ; Alaa Ismail ; Andaleeb Chowdhury ; Abdulhafez Selim ; Amr Abdelnasser

INTRODUCTION:

Significant proportions of liver cirrhotic patients develop hepatocellular carcinoma and have to undergo hepatic resection. The compromised cirrhotic liver cannot withstand further removal of hepatic tissue, thus, leading to postoperative complication and death.

METHODS:

In this study, we enrolled 20 patients having liver cirrhosis with hepatocellular carcinoma and randomly assigned them into two groups to receive autologous stem cells or placebo.

RESULTS:

After 3 weeks, all participants underwent liver resection and were followed for 12 weeks postoperative. We observed that the group receiving preoperative stem cell therapy had shown a significant improvement in all parameters of liver function and had no postoperative complications compared to the group treated with placebo, which showed no improvement in liver parameters and had postoperative complications.

DISCUSSION:

In conclusion, autologous stem cell therapy can improve the surgical outcome in cirrhotic livers and should be considered as an adjuvant treatment in such patients undergoing hepatic resection.

100 Deals associated with Autologous Stem Cells(El-Rayadh Fertility Centre)

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