Last update 07 Jun 2025

DE-104

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
DE 104
Target
ROCK
Action
inhibitors
Mechanism
ROCK inhibitors(Rho-associated kinases inhibitors)
Therapeutic Areas
Eye Diseases
Active Indication-
Inactive Indication
GlaucomaGlaucoma, Open-Angle
Originator Organization
UBE Corp.UBE Corp.
Active Organization-
Inactive Organization
UBE Corp.UBE Corp.Santen Pharmaceutical Co., Ltd.Santen Pharmaceutical Co., Ltd.
License Organization-
Drug Highest PhaseDiscontinuedPhase 2
First Approval Date-
Regulation-
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Related

4
Clinical Trials associated with DE-104
NCT00868894
/ CompletedPhase 1/2
A Randomized, Double-masked, Placebo- and Active-controlled, Multi-Center, Dose Escalation Trial of DE-104 Ophthalmic Solution in Japanese and Non-Japanese Subjects With Primary Open-angle Glaucoma or Ocular Hypertension
NCT00650338
/ CompletedPhase 2
A Randomized, Double-masked, Placebo- and Active- Controlled, Parallel-group, Multi-center, Dose-response Trial of DE-104 Ophthalmic Solution in Subjects With Primary Open-angle Glaucoma or Ocular Hypertension
NCT00656240
/ CompletedPhase 2
A Randomized, Double-Masked, Parallel-Group Trial of DE-104 Ophthalmic Solution in Subjects With Open-Angle Glaucoma or Ocular Hypertension
100 Clinical Results associated with DE-104
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100 Translational Medicine associated with DE-104
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100 Patents (Medical) associated with DE-104
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100 Deals associated with DE-104
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External Link

KEGGWikiATCDrug Bank
-DE-104--

R&D Status

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IndicationHighest PhaseCountry/LocationOrganizationDate
Glaucoma, Open-AnglePhase 2
United States
Santen Pharmaceutical Co., Ltd.Santen Pharmaceutical Co., Ltd.
01 Mar 2008
GlaucomaPhase 2-
UBE Corp.UBE Corp.
-
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Clinical Result

Indication
Phase
Evaluation
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Deal

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Clinical Trial

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Approval

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Regulation

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