[Translation] A randomized, double-blind, dose-response controlled, multicenter clinical trial to evaluate the safety and efficacy of the treatment of chronic hepatitis B

初步评价该药物：①安全性和不良反应；②治疗慢性乙型肝炎的临床疗效；③不同剂量的疗效和安全性的差异。

[Translation]

To preliminarily evaluate the drug: ① safety and adverse reactions; ② clinical efficacy in the treatment of chronic hepatitis B; ③ differences in efficacy and safety at different doses.

Start Date20 Apr 2006

Sponsor / Collaborator

Jilin Aodong Yanbian Pharmaceutical Co., Ltd.

100 Clinical Results associated with Gandakang Capsule

100 Translational Medicine associated with Gandakang Capsule

100 Patents (Medical) associated with Gandakang Capsule

Literatures (Medical) associated with Gandakang Capsule

01 Jan 2023·Evidence-Based Complementary and Alternative Medicine

Retracted: Clinical Efficacy of Gandakang Tablets plus Methylprednisolone in Patients with Systemic Lupus Erythematosus

Author: and Alternative Medicine, Evidence-Based Complementary ; And Alternative Medicine, Evidence-Based Complementary

[This retracts the article DOI: 10.1155/2022/4797454.].

28 Apr 2022·Evidence-Based Complementary and Alternative MedicineQ4 · MEDICINE

Clinical Efficacy of Gandakang Tablets plus Methylprednisolone in Patients with Systemic Lupus Erythematosus

Q4 · MEDICINE

ArticleOA

Author: Wang, Huanan ; Huang, Yanni ; Wang, Min ; Wang, Shanzhi ; Li, Guoquan ; Ye, Feng ; Guo, Feng

Objective. To evaluate the clinical efficacy of Gandakang tablets plus methylprednisolone in patients with systemic lupus erythematosus (SLE). Methods. From February 2015 to February 2019, 60 eligible patients with SLE were recruited and assigned via the random number table method at a ratio of 1 : 1 to receive either methylprednisolone (control group) or Gandakang tablets plus methylprednisolone (observation group). The primary endpoint was clinical efficacy, and the secondary endpoints included Systemic Lupus Erythematosus Disease Activity Index (SLEDAI) score, immunoglobulin (Ig), inflammatory factor levels, and adverse events. Results. Gandakang tablets plus methylprednisolone were associated with a significantly higher treatment efficacy versus methylprednisolone alone (

P < 0.05

). Gandakang tablets plus methylprednisolone resulted in significantly lower SLEDAI scores and lower levels of IgG, IgM, IgA, tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4), and interleukin-6 (IL-6) versus single medication of methylprednisolone (

P < 0.05

). The two groups showed a similar incidence of adverse events (

P > 0.05

). Patients given Gandakang tablets plus methylprednisolone had higher mental health, emotional role, physical role, social functioning, and bodily pain scores versus those receiving the monotherapy of methylprednisolone (

P < 0.05

). Conclusion. Gandakang tablets plus methylprednisolone is effective in the treatment of SLE by enhancing the patients’ immunity, mitigating the inflammatory response, eliminating negative emotions, and improving their quality of life.

100 Deals associated with Gandakang Capsule

R&D Status

10 top approved records.

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Indication	Country/Location	Organization	Date
Hepatitis B, Chronic	CN	Jilin Aodong Yanbian Pharmaceutical Co., Ltd.	08 Jan 2020

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