Last update 04 Dec 2025

JNJ-4355

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
JNJ 4355, JNJ-78394355, JNJ4355
Target
Mcl-1
Action
inhibitors
Mechanism
Mcl-1 inhibitors(Induced myeloid leukemia cell differentiation protein Mcl-1 inhibitors)
Therapeutic Areas
NeoplasmsImmune System DiseasesHemic and Lymphatic Diseases
Active Indication
Acute Myeloid LeukemiaMultiple MyelomaNeoplasms
Inactive Indication-
Originator Organization
Janssen Pharmaceuticals, Inc.Janssen Pharmaceuticals, Inc.
Active Organization
Janssen Pharmaceutica NVJanssen Pharmaceutica NVJanssen Research & Development LLCJanssen Pharmaceuticals, Inc.Janssen Pharmaceuticals, Inc.
Inactive Organization-
License Organization-
Drug Highest PhasePreclinical
First Approval Date-
Regulation-

Structure/Sequence

Molecular FormulaC40H43ClFN5O5S
InChIKeyLUVOYGUFQRWXGQ-UHFFFAOYSA-N
CAS Registry2697112-32-4

Related

100 Clinical Results associated with JNJ-4355
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100 Translational Medicine associated with JNJ-4355
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100 Patents (Medical) associated with JNJ-4355
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1
Literatures (Medical) associated with JNJ-4355
15 Jul 2022ACS Catalysis
Synthesis of Atropisomeric Biaryls via Chiral Suzuki–Miyaura/Enzymatic Kinetic Resolution
100 Deals associated with JNJ-4355
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R&D Status

10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Acute Myeloid LeukemiaPreclinical
United States
Janssen Research & Development LLC
18 Aug 2025
Acute Myeloid LeukemiaPreclinical
Belgium
Janssen Pharmaceutica NVJanssen Pharmaceutica NV
18 Aug 2025
Multiple MyelomaPreclinical
United States
Janssen Research & Development LLC
18 Aug 2025
Multiple MyelomaPreclinical
Belgium
Janssen Pharmaceutica NVJanssen Pharmaceutica NV
18 Aug 2025
NeoplasmsPreclinical
United States
Janssen Pharmaceuticals, Inc.Janssen Pharmaceuticals, Inc.
26 Mar 2024
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
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Clinical Trial

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Approval

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Regulation

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